The tumour suppressor protein p53 is stabilized by the de-ubiquitination enzyme herpes-virus-associated ubiquitin-specific protease (HAUSP), which localizes to the promyelocytic leukaemia nuclear body (PML-NB). The pro-apoptotic activity of p53 is also induced by HAUSP. Therefore, p53 ubiquitination is a dynamic process, and HAUSP might function as a tumour suppressor by enhancing p53 stabilization.
- Paolo Salomoni
- Pier Paolo Pandolfi