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Showing 1–11 of 11 results
Advanced filters: Author: P Schwille Clear advanced filters

  • Scientists are captivated by the prospect of creating a fully synthetic cell, offering the potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of experts discusses the definitions of a synthetic cell and highlights current achievements, challenges and future opportunities of building such systems.

    • Katarzyna P. Adamala
    • Marileen Dogterom
    • T-Y Dora Tang
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 162-167

  • Three-dimensional printed protein-based robotic structures are actuated by exoskeleton-like coats of molecular motor assemblies upon the spatially targeted release of chemical fuel, resulting in micrometre-scale shape-morphing activity.

    • Haiyang Jia
    • Johannes Flommersfeld
    • Petra Schwille
    ResearchOpen Access
    Nature Materials
    Volume: 21, P: 703-709

  • Synthetic cells are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. In this perspective, the authors highlight major scientific hurdles, such as the integration of functional modules by ensuring compatibility across diverse synthetic subsystems, and propose strategies to advance the field.

    • S. Giaveri
    • Z. Abil
    • I. N. Westensee
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-6

  • Chemical systems can show complex behaviour that is not seen in individual molecules or reactions. Helena S. Azevedo, Sarah L. Perry, Peter A. Korevaar, and Dibyendu Das report on the emergence of this complex behaviour, which was discussed at the Virtual Symposium on Systems Chemistry

    • Helena S. Azevedo
    • Sarah L. Perry
    • Dibyendu Das
    News & Views
    Nature Chemistry
    Volume: 12, P: 793-794

  • It is unclear whether viral particles can induce membrane curvature. Binding of Simian virus 40 (SV40) to the GM1 ganglioside on host plasma membranes leads to membrane curvature and the formation of invaginations in cells and in giant unilamellar vesicles, an effect required for viral infection.

    • Helge Ewers
    • Winfried Römer
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 12, P: 11-18

  • Bottom-up synthetic biology might greatly benefit from custom-made proteins as components of new biological systems. This Review discusses various protein optimization and design approaches, and explores how these can contribute to the generation of controllable synthetic cells.

    • Béla P. Frohn
    • Shunshi Kohyama
    • Petra Schwille
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 645-659

  • By encapsulating proteins in giant unilamellar vesicles, Bashirzadeh et al find that actin crosslinkers, α-actinin and fascin, can self-assemble with actin into complex structures that depend on the degree of confinement. Further analysis and modeling show that α-actinin and fascin sort to separate domains of these structures. These insights may be generalizable to other biopolymer networks containing crosslinkers.

    • Yashar Bashirzadeh
    • Steven A. Redford
    • Allen P. Liu
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11