Nature Search

Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer

K J O’Byrne
N Dobbs
A L Harris
ResearchOpen Access26 Feb 1999
British Journal of Cancer

Volume: 79, P: 1413-1418
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Cox and colleagues develop PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor and show that it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.

Jessica L. Chitty
Michelle Yam
Thomas R. Cox
ResearchOpen Access28 Aug 2023
Nature Cancer

Volume: 4, P: 1326-1344
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.

Claire Vennin
Pauline Mélénec
Paul Timpson
ResearchOpen Access12 Aug 2019
Nature Communications

Volume: 10, P: 1-22
Carbonate mud production in lakes is driven by degradation of microbial substances

Microbial activity is a major control in carbonate mud precipitation and mineralization even after 2000 years of deposition if there is degradable organic matter, according to bio- physiochemical analysis of core sediments from Lake Ilay, France.

P. Boussagol
E. Vennin
P. T. Visscher
ResearchOpen Access30 Sept 2024
Communications Earth & Environment

Volume: 5, P: 1-9
Plasma insulin-like growth factor binding protein-3 proteolysis is increased in primary breast cancer

S I Helle
S Geisler
P E Lønning
ResearchOpen Access03 Jul 2001
British Journal of Cancer

Volume: 85, P: 74-77
Cancer of the endometrium

A Brémond
A Bataillard
J Pigneux
ResearchOpen Access01 May 2001
British Journal of Cancer

Volume: 84, P: 31-36
Ovarian cancer

P Kerbrat
C Lhommé
J Dauplat
ResearchOpen Access01 May 2001
British Journal of Cancer

Volume: 84, P: 18-23
Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide

I Noci
P Borri
G L Taddei
ResearchOpen Access31 Jul 2001
British Journal of Cancer

Volume: 85, P: 333-336
Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line

J P Parisot
X F Hu
J R Zalcberg
ResearchOpen Access29 Jan 1999
British Journal of Cancer

Volume: 79, P: 693-700
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Vinod P. Balachandran
Marta Łuksza
Steven D. Leach
Research01 Nov 2017
Nature

Volume: 551, P: 512-516
Exceptional fossil assemblages confirm the existence of complex Early Triassic ecosystems during the early Spathian

Christopher P. A. Smith
Thomas Laville
Arnaud Brayard
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-12
Modern arsenotrophic microbial mats provide an analogue for life in the anoxic Archean

Arsenic-consuming microbes of the hypersaline Laguna La Brava in Chile may be an analogue for early life during the anoxic conditions of the Archean, according to geochemical and metagenomic analyses of the extant microbial mats

Pieter T. Visscher
Kimberley L. Gallagher
Christophe Dupraz
ResearchOpen Access22 Sept 2020
Communications Earth & Environment

Volume: 1, P: 1-10
Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

James R. W. Conway
Claire Vennin
Paul Timpson
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

A Jakubowska
D Rozkrut
J Lubinski
ResearchOpen Access15 May 2012
British Journal of Cancer

Volume: 106, P: 2016-2024
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

N L E Harris
C Vennin
D N Saunders
ResearchOpen Access27 Mar 2017
Oncogene

Volume: 36, P: 4288-4298
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Lakis et al. report novel findings related to the epigenetic landscape of pancreatic neuroendocrine cancer. This relatively large cohort provides functional insights into the epigenetic wiring of pancreatic neuroendocrine tumor sub-types with the potential ability to stratify tumours of different prognosis.

Vanessa Lakis
Rita T. Lawlor
Aldo Scarpa
ResearchOpen Access03 Feb 2021
Communications Biology

Volume: 4, P: 1-11
Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers

Logan C Walker
Louise Marquart
Amanda B Spurdle
ResearchOpen Access01 Feb 2017
European Journal of Human Genetics

Volume: 25, P: 432-438
Developments in preclinical cancer imaging: innovating the discovery of therapeutics

Conway and colleagues provide a comprehensive overview of imaging techniques as pertaining to their use in identifying new drugs for cancer therapy.

James R. W. Conway
Neil O. Carragher
Paul Timpson
Reviews17 Apr 2014
Nature Reviews Cancer

Volume: 14, P: 314-328
The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

I Roth
H Campbell
A W Braithwaite
Research21 Mar 2016
Oncogene

Volume: 35, P: 4981-4989
Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

A Osorio
R L Milne
J Benítez
ResearchOpen Access17 Nov 2009
British Journal of Cancer

Volume: 101, P: 2048-2054

Search

Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer

A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Carbonate mud production in lakes is driven by degradation of microbial substances

Plasma insulin-like growth factor binding protein-3 proteolysis is increased in primary breast cancer

Cancer of the endometrium

Ovarian cancer

Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide

Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Exceptional fossil assemblages confirm the existence of complex Early Triassic ecosystems during the early Spathian

Modern arsenotrophic microbial mats provide an analogue for life in the anoxic Archean

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers

Developments in preclinical cancer imaging: innovating the discovery of therapeutics

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

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