Reitz et al. show that targeting the circadian regulator REV-ERB for just one day after myocardial ischemia-reperfusion benefits cardiac repair by reducing the NLRP3 inflammasome and immune recruitment to infarcted myocardium, and thus preventing the development of heart failure.
- Cristine J. Reitz
- Faisal J. Alibhai
- Tami A. Martino