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Showing 1–12 of 12 results
Advanced filters: Author: P. Gönczy Clear advanced filters

  • Centrioles are essential for the formation of centrosomes, cilia and flagella. The centriolar protein Polo-like-kinase 4 (Plk4) is a key regulator of centriole biogenesis and for maintaining constant centriole number in cells. These authors show that the centriolar protein Asterless (CEP152 in humans) interacts with Plk4 and Sas-4. They find that Asl functions as a scaffold for Plk4 and Sas-4 that facilitates self-assembly and duplication of the centriole, and organization of pericentriolar material.

    • Nikola S. Dzhindzhev
    • Quan D. Yu
    • David M. Glover
    Research
    Nature
    Volume: 467, P: 714-718

  • Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal instability.

    • Gaëlle Marteil
    • Adan Guerrero
    • Mónica Bettencourt-Dias
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The centriole is an organelle composed of rings of SAS-6 proteins that form a cartwheel structure. Here the authors develop a cell-free system to examine core cartwheel assembly ofC. reinhardtiiproteins and discover that CrSAS-6 has autonomous properties that facilitates self-organized stacking of pairs of rings.

    • P. Guichard
    • V. Hamel
    • P. Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • The centriole exhibits an evolutionarily conserved 9-fold radial symmetry that stems from a cartwheel containing vertically stacked ring polymers that harbor 9 homodimers of the protein SAS-6. Here the authors show how dual properties inherent to surface-guided SAS-6 self-assembly possess spatial information that dictates correct scaffolding of centriole architecture.

    • Niccolò Banterle
    • Adrian P. Nievergelt
    • Pierre Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Microtubule asters are positioned precisely within cells by forces generated by molecular motors, but it is unclear how these are integrated in space and time. Here the authors perform in vivo drag measurements and genetic manipulations to determine the balance of forces that position microtubule asters in C. elegans zygotes.

    • A. De Simone
    • A. Spahr
    • P. Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Behaviour drives infection risk in social groups. Here, Li et al. show that depending on the behavioural role of clonal ants in a colony, genetically identical individuals face vastly different risks of becoming infected with parasitic nematodes.

    • Zimai Li
    • Bhoomika Bhat
    • Yuko Ulrich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Carrying out high-throughput, cell-based RNA interference screens involves making a range of decisions, from choosing the cell type and reagents to picking strategies for optimization and validation. Informed planning at each stage allows the power of this approach to be maximized.

    • Christophe J. Echeverri
    • Norbert Perrimon
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 373-384