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Showing 1–4 of 4 results
Advanced filters: Author: Paari Dominic Clear advanced filters

  • The hormone aldosterone can damage the heart after myocardial infarction, such that drugs that inhibit its action are often prescribed. B. Julie He et al. now uncover a new pathway underlying the detrimental effects of aldosterone action: oxidation of the enzyme Ca2+/calmodulin-dependent protein kinase II leads to its activation and increased expression of the metalloprotease MMP9 in cardiac muscle cells, thereby promoting cardiac rupture.

    • B Julie He
    • Mei-ling A Joiner
    • Mark E Anderson
    Research
    Nature Medicine
    Volume: 17, P: 1610-1618

  • Hydrogen sulfide (H2S) is a gaseous signalling molecule with important roles in cardiovascular health and disease. In this Review, Kevil and colleagues discuss the role of H2S, its synthesizing enzymes and metabolites, their roles in the cardiovascular system, and their involvement in cardiovascular disease and associated pathologies.

    • Gopi K. Kolluru
    • Rodney E. Shackelford
    • Christopher G. Kevil
    Reviews
    Nature Reviews Cardiology
    Volume: 20, P: 109-125

  • Chowdhury Abdulla and Richa Aishwarya et al. report that methamphetamine exposure in mice leads to cardiomyopathy via the signaling receptor Sigmar1. They find that methamphetamine inhibits Sigmar1, which alters mitochondrial function, and show that their findings are consistent with observations in hearts from human methamphetamine users.

    • Chowdhury S. Abdullah
    • Richa Aishwarya
    • Md. Shenuarin Bhuiyan
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-20