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Showing 1–10 of 10 results
Advanced filters: Author: Pablo Cruz-Morales Clear advanced filters

  • A comprehensive assessment of biotic and abiotic features of cacao fermentation led to the design of a defined microbial consortium that could reproduce the fine flavour profile of chocolate under controlled conditions.

    • Pablo Cruz-Morales
    News & Views
    Nature Microbiology
    Volume: 10, P: 2102-2103

  • The α-diazoester azaserine can be produced by Streptomyces albus engineered with a biosynthetic gene cluster and act as the carbene precursor for coupling with intracellularly produced styrene to generate unnatural amino acids containing a cyclopropyl group.

    • Jing Huang
    • Andrew Quest
    • Jay D. Keasling
    Research
    Nature
    Volume: 617, P: 403-408

  • Fungi have the potential to produce sustainable foods for a growing population, but current products are based on a small number of strains with inherent limitations. Here, the authors develop genetic tools for an edible fungus and engineer its nutritional value and sensory appeal for alternative meat applications.

    • Vayu Maini Rekdal
    • Casper R. B. van der Luijt
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze the final step of lysine catabolism in plants.

    • Mitchell G. Thompson
    • Jacquelyn M. Blake-Hedges
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Two bioinformatic tools, BiG-SCAPE and CORASON, enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.

    • Jorge C. Navarro-Muñoz
    • Nelly Selem-Mojica
    • Marnix H. Medema
    Research
    Nature Chemical Biology
    Volume: 16, P: 60-68

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631