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Showing 1–17 of 17 results
Advanced filters: Author: Pablo I. Nikel Clear advanced filters

  • Biosensors are powerful tools for quantification of a wide range of molecules but require extensive engineering for each analyte. Here, the authors engineered a robust environmental bacterium for sensing a diverse set of chemicals, such as lactate and PET degradation products, via growth-coupling

    • Javier M. Hernández-Sancho
    • Arnaud Boudigou
    • Pablo I. Nikel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

    • Giusi Favoino
    • Òscar Puiggené
    • Pablo I. Nikel
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for sensing glyoxylate and glycolate, with applications in pathway engineering and environmental monitoring.

    • Enrico Orsi
    • Helena Schulz-Mirbach
    • Pablo I. Nikel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engineered Pseudomonas putida.

    • Patricia Calero
    • Daniel C. Volke
    • Pablo I. Nikel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • This Perspective assesses the opportunities and challenges for synthetic biology in revolutionizing agriculture, and highlights the resources and approaches we need to remove the barriers and propel another Green Revolution.

    • Eleanore T. Wurtzel
    • Claudia E. Vickers
    • Tobias J. Erb
    Reviews
    Nature Plants
    Volume: 5, P: 1207-1210

  • Much of synthetic biology research makes use of model organisms, such asEscherichia coli. Here, Víctor de Lorenzo and colleagues emphasize the need for a wider choice of model organisms and advocate the use of environmental Pseudomonasstrains as model organisms that possess the necessary metabolic traits required to meet current and future synthetic biology and biotechnological needs.

    • Pablo I. Nikel
    • Esteban Martínez-García
    • Víctor de Lorenzo
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 368-379

  • Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

    • Enrico Orsi
    • Nico J. Claassens
    • Steffen N. Lindner
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-5

  • Achieving cost-competitive bio-based processes requires development of stable and selective biocatalysts. In this Perspective, the authors propose an integrated solution combining growth-coupled selection with machine learning and automated workflows to accelerate development pipelines.

    • Enrico Orsi
    • Lennart Schada von Borzyskowski
    • Steffen N. Lindner
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Using one carbon (C1) molecules as primary feedstock for bioproduction holds great potential for a circular and carbon neutral economy. Here, the authors discuss the potential of merging knowledge gained from natural and synthetic C1-trophic organisms to expedite the development of efficient C1-based biomanufacturing.

    • Enrico Orsi
    • Pablo Ivan Nikel
    • Stefano Donati
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Establishing biotechnological alternatives to chemical syntheses requires the rational design of biosynthetic pathways and degradation routes either as enzymatic cascades in vitro or as part of living organisms. Here, the authors use alanine dehydrogenase from Vibrio proteolyticus and the diaminopimelate dehydrogenase from Symbiobacterium thermophilum for the in vitro production of (R) and (S)-3-fluoroalanine, reaching >85% yield with complete enantiomeric excess.

    • Manuel Nieto-Domínguez
    • Aboubakar Sako
    • Pablo I. Nikel
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-11

  • Non-model bacteria offer unique and versatile metabolisms for synthetic biology. In this Perspective, the authors explore the limited availability of well-characterised biological parts in these species and argue that bacteriophages represent a diverse trove of orthogonal parts.

    • Eveline-Marie Lammens
    • Pablo Ivan Nikel
    • Rob Lavigne
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-14