Nature Search

The thermal stability of near-surface ground ice on Mars

David A. Paige
Research05 Mar 1992
Nature

Volume: 356, P: 43-45
Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

Katelyn E. Connelly
Katherine Hullin
Laufey T. Amundadottir
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

Alison P. Klein
Brian M. Wolpin
Laufey T. Amundadottir
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.

Brian M Wolpin
Cosmeri Rizzato
Laufey T Amundadottir
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 994-1000
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Mitchell J. Machiela
Weiyin Zhou
Stephen J. Chanock
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Colton J. Bracken
Shion A. Lim
James A. Wells
Research20 Oct 2020
Nature Chemical Biology

Volume: 17, P: 113-121
Discovery of VH domains that allosterically inhibit ENPP1

Phage and yeast display were used to generate variable heavy single-domain antibodies that bind and allosterically inhibit ectodomain phosphatase/phosphodiesterase-1 to increase the half-life of the immune-stimulant cyclic guanosine monophosphate adenosine monophosphate (cGAMP) in tumor microenvironments.

Paige E. Solomon
Colton J. Bracken
James A. Wells
ResearchOpen Access03 Jul 2023
Nature Chemical Biology

Volume: 20, P: 30-41
Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Kevin B Jacobs
Meredith Yeager
Stephen J Chanock
Research06 May 2012
Nature Genetics

Volume: 44, P: 651-658
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Anaerobic microsites have an unaccounted role in soil carbon stabilization

Mechanisms controlling soil carbon storage and feedbacks to the climate system remain poorly constrained. Here, the authors show that anaerobic microsites stabilize soil carbon by shifting microbial metabolism to less efficient anaerobic respiration and protecting reduced organic compounds from decomposition.

Marco Keiluweit
Tom Wanzek
Scott Fendorf
ResearchOpen Access24 Nov 2017
Nature Communications

Volume: 8, P: 1-10
Biocultural approaches to well-being and sustainability indicators across scales

Biocultural approaches combining local values, knowledge, and needs with global ecological factors provide a fruitful indicator framework for assessing local and global well-being and sustainability, and help bridge the divide between them.

Eleanor J. Sterling
Christopher Filardi
Stacy D. Jupiter
Reviews23 Oct 2017
Nature Ecology & Evolution

Volume: 1, P: 1798-1806
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Stephen Chanock and colleagues report a genome-wide association study of pancreatic cancer. They identify common variants at the ABO blood group locus associated with susceptibility to pancreatic cancer, consistent with previous epidemiological evidence suggesting that individuals with A or B blood types have greater risk of this cancer than individuals with blood type O.

Laufey Amundadottir
Peter Kraft
Robert N Hoover
Research02 Aug 2009
Nature Genetics

Volume: 41, P: 986-990
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Stephen Chanock and colleagues identify three new susceptibility loci for pancreatic cancer on chromosomes 13q22.1, 1q32.1 and 5p15.33. The association signal at 13q22.1 maps to a large nongenic region, whereas the signals at 1q32.1 and 5p15.33 map near the NR5A2 gene and CPTM1L-TERT region, respectively.

Gloria M Petersen
Laufey Amundadottir
Stephen J Chanock
Research24 Jan 2010
Nature Genetics

Volume: 42, P: 224-228
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Alison Klein and colleagues report a genome-wide meta-analysis to identify loci associated with pancreatic cancer risk. They identify associated variants at 17q25.1, 3q29, 7p13 and 2p13.3.

Erica J Childs
Evelina Mocci
Alison P Klein
Research22 Jun 2015
Nature Genetics

Volume: 47, P: 911-916
Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation

Steven J. Korzeniewski
Elizabeth N. Allred
Katherine M. Solomon
ResearchOpen Access08 Jun 2018
Translational Psychiatry

Volume: 8, P: 1-10
An examination of exposure measurement error from air pollutant spatial variability in time-series studies

Stefanie E Sarnat
Mitchel Klein
Paige E Tolbert
Research11 Mar 2009
Journal of Exposure Science & Environmental Epidemiology

Volume: 20, P: 135-146
Analysis of telomerase as a diagnostic biomarker of cervical dysplasia and carcinoma

Elke A Jarboe
Kai-Li Liaw
Kenneth R Shroyer
Reviews11 Feb 2002
Oncogene

Volume: 21, P: 664-673

Search

The thermal stability of near-surface ground ice on Mars

Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Discovery of VH domains that allosterically inhibit ENPP1

Detectable clonal mosaicism and its relationship to aging and cancer

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Anaerobic microsites have an unaccounted role in soil carbon stabilization

Biocultural approaches to well-being and sustainability indicators across scales

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation

An examination of exposure measurement error from air pollutant spatial variability in time-series studies

Analysis of telomerase as a diagnostic biomarker of cervical dysplasia and carcinoma

Search

Quick links

Search

Filter By:

Search

Quick links