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Showing 1–6 of 6 results

Advanced filters: Author: Palaniraja Thandapani Clear advanced filters

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Analysis of 3D chromatin architecture in T-ALL identifies differences in intra-TAD interactions and TAD boundary insulation. Inhibition of oncogenic signal transduction or epigenetic regulation can alter specific 3D interactions.

Andreas Kloetgen
Palaniraja Thandapani
Aristotelis Tsirigos
Research23 Mar 2020
Nature Genetics

Volume: 52, P: 388-400
Valine tRNA levels and availability regulate complex I assembly in leukaemia

Restriction of dietary valine reduces growth of T cell acute lymphoblastic leukaemia through altered valine tRNA biogenesis and reduced translation of mRNAs that encode subunits of mitochondrial complex I.

Palaniraja Thandapani
Andreas Kloetgen
Iannis Aifantis
Research22 Dec 2021
Nature

Volume: 601, P: 428-433
RNA-binding proteins, the guardians of the marginal zone

RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells.

Palaniraja Thandapani
Beatriz Aranda-Orgilles
Iannis Aifantis
News & Views18 May 2017
Nature Immunology

Volume: 18, P: 595-597
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

El-Hachem et al. show that MAPK therapy upregulates valine aminoacyl-tRNA synthetase and alters fatty acid oxidation by promoting translation of valine-enriched transcripts, providing a resistance mechanism that may be therapeutically targeted.

Najla El-Hachem
Marine Leclercq
Pierre Close
ResearchOpen Access07 Jun 2024
Nature Cell Biology

Volume: 26, P: 1154-1164
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening

Deep learning predicts cell-type-specific 3D chromatin contacts from DNA sequence, chromatin accessibility and CTCF binding.

Jimin Tan
Nina Shenker-Tauris
Aristotelis Tsirigos
ResearchOpen Access09 Jan 2023
Nature Biotechnology

Volume: 41, P: 1140-1150
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Aifantis and colleagues use leukemic cell lines to identify modulators of CD19 expression that have the potential to improve therapeutic strategies.

Matthew T. Witkowski
Soobeom Lee
Iannis Aifantis
Research22 Sept 2022
Nature Immunology

Volume: 23, P: 1424-1432