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Showing 1–5 of 5 results
Advanced filters: Author: Pallavur Sivakumar Clear advanced filters

  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis involving evasion of immune control. Here, the authors perform a comprehensive analysis of single-cell multi-omic data revealing either a myeloid-enriched or adaptive-enriched tumour microenvironment, linked to distinct B and T cell clonal selection and differentiation, distinct overall survival, and potential therapeutic approaches.

    • Shivan Sivakumar
    • Ashwin Jainarayanan
    • Rachael Bashford-Rogers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Interleukin 21 (IL21) is an immune-stimulating cytokine that has demonstrated antitumour activity in preclinical models and has recently entered clinical trials. Here, the authors discuss the antitumour effects of IL21 and describe strategies to combine IL21 with other drugs for future cancer therapies.

    • Kresten Skak
    • Michael Kragh
    • Pallavur V. Sivakumar
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 231-240

  • Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.

    • Miriam Meyer
    • Andrea Mahr
    • Cedrik M. Britten
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 23, P: 1-2