Nature Search

Cell diversity and plasticity during atrioventricular heart valve EMTs

Lotto et al. delineate cell diversity and mechanisms during heart valve development using scRNA-seq. They identify distinct cell types and states, the emergence of epithelial-mesenchymal plasticity, and cell interactions that may govern this process.

Jeremy Lotto
Rebecca Cullum
Pamela A. Hoodless
ResearchOpen Access09 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Fetal liver development and implications for liver disease pathogenesis

Advances in single-cell technologies and lineage tracing have improved our understanding of liver development. In this Review, Hoodless and colleagues discuss the formation of liver parenchymal and non-parenchymal cell types, and describe emerging parallels between early liver development and the pathogenesis of liver injury.

Jeremy Lotto
Tabea L. Stephan
Pamela A. Hoodless
Reviews19 May 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 561-581
The emergent landscape of the mouse gut endoderm at single-cell resolution

The developing mouse gut endoderm, mapped at single-cell resolution, reveals trajectories of cell differentiation before and during gastrulation and the emergence of regionalized cell identities along the anterior–posterior axis of the gut tube.

Sonja Nowotschin
Manu Setty
Dana Pe’er
Research08 Apr 2019
Nature

Volume: 569, P: 361-367
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation

Mutations in the transcription factor MEF2B are found in diffuse large B-cell lymphoma. In this study, the authors map the DNA-binding sites of the transcription factor in cells in vitroand find that the mutations decrease the ability of MEF2B to activate transcription.

Julia R. Pon
Jackson Wong
Marco A. Marra
ResearchOpen Access06 Aug 2015
Nature Communications

Volume: 6, P: 1-15
HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

An interaction between hepatocyte nuclear factor 4A (HNF4A) and the MLL4 complex is important for histone modifications at cis regulatory regions to alter gene expression in vivo and in vitro.

Avinash Thakur
Kwangjin Park
Pamela A. Hoodless
ResearchOpen Access31 Jan 2024
Communications Biology

Volume: 7, P: 1-14
De novo assembly and analysis of RNA-seq data

The Trans-ABySS pipeline is an integrated approach for transcript assembly and analysis to identify new mRNA isoforms and structures.

Gordon Robertson
Jacqueline Schein
Inanc Birol
Research10 Oct 2010
Nature Methods

Volume: 7, P: 909-912
G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression

Cheng, Fan, Li et al. identified ANGPTL4 as a G1-induced target gene of GPER/YAP in HRT8 cells using RNA-seq and highlighted its importance in regulating trophoblast cell invasion. The authors also reported GPER downregulation in the placenta and lower estradiol levels in patients who developed preeclampsia.

Jung-Chien Cheng
Lanlan Fang
Ying-Pu Sun
ResearchOpen Access12 Nov 2021
Communications Biology

Volume: 4, P: 1-12
Elucidating the importance and regulation of key enhancers for human MEIS1 expression

Ping Xiang
Xining Yang
Arefeh Rouhi
ResearchOpen Access27 May 2022
Leukemia

Volume: 36, P: 1980-1989

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Cell diversity and plasticity during atrioventricular heart valve EMTs

Fetal liver development and implications for liver disease pathogenesis

The emergent landscape of the mouse gut endoderm at single-cell resolution

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation

HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

De novo assembly and analysis of RNA-seq data

G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression

Elucidating the importance and regulation of key enhancers for human MEIS1 expression

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