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Showing 1–5 of 5 results
Advanced filters: Author: Pamela Kakimoto Clear advanced filters

  • GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin and PPAR activity.

    • Daniela Liskiewicz
    • Aaron Novikoff
    • Timo D. Müller
    ResearchOpen Access
    Nature
    P: 1-10

  • Sex profoundly shapes liver metabolism, with oestrogens conferring protection against metabolic liver disease. In this study, Yang, Wang and colleagues identify the orphan G protein-coupled receptor GPR110 as a liver-specific brake on oestrogen signalling, bridging GPCR and nuclear receptor pathways, thus pointing to GPR110 as a target for sex-specific therapy in liver disease.

    • Pamela Kakimoto
    • Natalie Krahmer
    News & Views
    Nature Metabolism
    Volume: 8, P: 8-9

  • Klingelhuber, Frendo-Cumbo et al. develop a proteomic atlas elucidating the intracellular spatiotemporal changes in protein levels and localizations during human adipogenesis.

    • Felix Klingelhuber
    • Scott Frendo-Cumbo
    • Natalie Krahmer
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 861-879