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Showing 1–5 of 5 results
Advanced filters: Author: Panagiotis Kotsantis Clear advanced filters

  • Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.

    • Panagiotis Kotsantis
    • Lara Marques Silva
    • Eva Petermann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR), but its role in DDR-deficient cancers remains unclear. Here, the authors find EXO1 loss as synthetic lethal with many DDR genes involved in various cancers, including genes from Fanconi Anaemia pathway, BRCA1-A complex, and spliceosome factor ZRSR2; such interactions represent potential clinical targets.

    • Marija Maric
    • Sandra Segura-Bayona
    • Simon J. Boulton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • A phospho-switch is identified in the shelterin subunit TRF2 that regulates transient recruitment of the RTEL1 helicase to, and release from, telomeres, and provides a narrow window during which RTEL1 can unwind t-loops to facilitate telomere replication.

    • Grzegorz Sarek
    • Panagiotis Kotsantis
    • Simon J. Boulton
    Research
    Nature
    Volume: 575, P: 523-527

  • The tumour suppressor ARF regulates p53 levels; however, in contrast to p53, ARF has not been implicated in the response to DNA damage. In this study, Carlos et al.show that single-stranded DNA formed in BRCA2-null cells triggers a DNA damage response leading to the activation of ARF and senescence.

    • Ana Rita Carlos
    • Jose Miguel Escandell
    • Madalena Tarsounas
    Research
    Nature Communications
    Volume: 4, P: 1-14