We developed a ROS-responsive and controllable nanocarrier (GC-EB) that efficiently delivered a clinically used antifungal drug, voriconazole (VOR). GC-EB-VOR exhibited high penetration through corneal barriers, good retention in the cornea and controllable drug release under low concentrations of ROS. Mechanistically, the successful delivery and accumulation of GC-EB-VOR in the cornea followed by the inhibition of oxidative stress and of the inflammatory response contributed to the therapeutic effect of GC-EB-VOR against fungal keratitis.
- Panhong Niu
- Yuelan Wu
- Hua Gao
