Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus. PML usually only develops in individuals who are immunocompromised, and can be caused by immunomodulatory therapies. In this article, Brew et al. review the literature relating to the diagnosis and management of PML. The authors also suggest practical management guidelines for this condition.
- Bruce J. Brew
- Nicholas W. S. Davies
- Avindra Nath
