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Showing 1–3 of 3 results
Advanced filters: Author: Paolo Cifani Clear advanced filters
  • Garg et al. determined structures of human Fructosamine-3-kinase (FN3K) bound with different nucleotide analogues and a small molecule sugar mimic substrate. Accompanied by biochemical analysis, they revealed features of the enzyme important for kinase activity and sugar moiety dynamics, providing mechanistic insights into FN3K function.

    • Ankur Garg
    • Kin Fan On
    • Leemor Joshua-Tor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Comprehensive CRISPR mutagenesis targeting all members of the NuRD complex identifies a specific subcomplex required for fetal globin silencing and informs a rational targeting strategy for elevating globin levels while avoiding cytotoxicity.

    • Falak Sher
    • Mir Hossain
    • Daniel E. Bauer
    Research
    Nature Genetics
    Volume: 51, P: 1149-1159