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Showing 1–2 of 2 results
Advanced filters: Author: Parinaaz Jalali Clear advanced filters

  • Here they demonstrate a therapeutic intervention elevating levels of CYP450-derived lipids to control the expansion of intermediate monocytes in tissue and peripheral blood, presenting a first in class therapeutic approach for treating chronic inflammatory disease.

    • Olivia V. Bracken
    • Parinaaz Jalali
    • Derek W. Gilroy
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • The post-resolution phase of inflammation is not simply a linear path towards cessation of immune response but rather a regulated process involving fluctuating immune activity. Here authors show a pivotal role for post-resolution macrophages in driving a wave of T cell recruitment and activation via prostaglandin E2 and α-integrin signalling during the resolution phase of murine pneumococcal pneumonia.

    • Karen T. Feehan
    • Hannah E. Bridgewater
    • Derek W. Gilroy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17