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Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Parinaz Mehdipour
Sajid A. Marhon
Daniel D. De Carvalho
Amendments and Corrections02 Mar 2021
Nature

Volume: 591, P: E20
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Inverted-repeat Alu elements are the main source of drug-induced immunogenic double-stranded RNAs, which are destabilized by the RNA deaminase ADAR1, thereby limiting activation of the immune response.

Parinaz Mehdipour
Sajid A. Marhon
Daniel D. De Carvalho
Research21 Oct 2020
Nature

Volume: 588, P: 169-173
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases

Xu, Kong, Li, Pisignano and colleagues provide a map of pseudouridine sites in human noncoding RNA. Using a systematic knockout approach, they associate each pseudouridine site with the activity of a specific pseudouridine synthase.

Haiqi Xu
Linzhen Kong
Chun-Xiao Song
ResearchOpen Access24 Oct 2025
Nature Cell Biology

Volume: 27, P: 2186-2197
Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

Here the authors suggest that in Atypical Teratoid Rhabdoid Tumors, EZH2 inhibition triggers a viral mimicry response via the activation of genes with intronic IR-Alu elements. This response also involves enhanced LINE-1 expression, leading to activation of cGAS/STING signalling.

Shengrui Feng
Sajid A. Marhon
Daniel D. De Carvalho
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-18
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Loss of MEN1 affects tumor growth, varing with the components of the tumor microenvironment. These tumors show redistribution of MLL1 on chromatin and the activation of a viral mimicry response.

Peiran Su
Yin Liu
Housheng Hansen He
ResearchOpen Access03 Sept 2024
Nature Genetics

Volume: 56, P: 1890-1902
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.

Qin Wu
David Y. Nie
Cheryl H. Arrowsmith
ResearchOpen Access16 May 2022
Nature Chemical Biology

Volume: 18, P: 821-830
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma

Self-renewing cells play an important role in initiation, progression, and therapy resistance in glioblastoma. Here, the authors identify histone variant macroH2A2 as a regulator of chromatin organisation resulting in the suppression of transcriptional programs of self-renewal in glioblastoma.

Ana Nikolic
Francesca Maule
Marco Gallo
ResearchOpen Access27 May 2023
Nature Communications

Volume: 14, P: 1-22
The next generation of DNMT inhibitors

DNA methyltransferase inhibitors are widely used in preclinical and clinical studies, but poor pharmacokinetics and low efficacy in solid tumors limit their therapeutic use. A new study reports the development and characterization of a specific, non-covalent DNA methyltransferase inhibitor with more-durable DNA hypomethylation and lower toxicity than that of nucleoside analogs.

Parinaz Mehdipour
Raymond Chen
Daniel D. De Carvalho
News & Views22 Oct 2021
Nature Cancer

Volume: 2, P: 1000-1001
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264

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