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Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion

Ovarian cancer cells invade and metastasize into adipose tissue. By designing biomimetic organo-hydrogels, the authors reveal how the mechanical anisotropy and microstructure of adipose tissues jointly guide invasive migration.

Jordi Gonzalez-Molina
Parisa Nabili
Julien E. Gautrot
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-15

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Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion

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