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Showing 1–4 of 4 results
Advanced filters: Author: Partho Sarothi Ray Clear advanced filters

  • Proteomic, transcriptomic, and genomic analysis has shown osteosarcoma (OS) to be a complex and heterogenous disease but revealed little about its carcinogenesis or potential therapeutic targets. Here, the authors profile the RNA interactome, transcriptome and proteome of cells derived from OS patients, identifying a targetable vulnerability to translation inhibition.

    • Yang Zhou
    • Partho Sarothi Ray
    • Andreas E. Kulozik
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • The binding of small ligands to RNAs is a mechanism for regulation of gene expression in bacteria, fungi and plants. This work describes the first RNA switch to be identified in human cells. This element in the 3′ UTR of the VEGFA mRNA can bind two different complexes, GAIT or HNRNPL. The binding of one induces a specific conformation that precludes binding of the other. Which factor is bound depends on environmental signals indicating inflammatory and hypoxic status.

    • Partho Sarothi Ray
    • Jie Jia
    • Paul L. Fox
    Research
    Nature
    Volume: 457, P: 915-919