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Showing 1–10 of 10 results

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Author Correction: Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia Maschalidi
Parul Mehrotra
Kodi S. Ravichandran
Amendments and Corrections27 Jul 2022
Nature

Volume: 608, P: E29
Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Defining the composition of the secretome of pyroptotic macrophages reveals the involvement of the component factors in wound healing.

Parul Mehrotra
Sophia Maschalidi
Kodi S. Ravichandran
Research26 Jun 2024
Nature

Volume: 631, P: 207-215
Metabolites released from apoptotic cells act as tissue messengers

Apoptotic cells communicate with neighbouring cells by the regulated release of specific metabolites, and a cocktail of select apoptotic metabolites reduces disease severity in mouse models of inflammatory arthritis and lung transplant rejection.

Christopher B. Medina
Parul Mehrotra
Kodi S. Ravichandran
Research18 Mar 2020
Nature

Volume: 580, P: 130-135
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Transcriptomic, genetic and pharmacological analysis identifies SLC7A11 as an inhibitor of efferocytosis in dendritic cells, and increased expression of this protein may cause slower wound healing in diabetes.

Sophia Maschalidi
Parul Mehrotra
Kodi S. Ravichandran
Research25 May 2022
Nature

Volume: 606, P: 776-784
Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance

Innate immunity is critical in the response to bacterial infection. Here the authors show a role for the nucleolar-associated protein fibrillarin in regulating the innate response to infection.

Varnesh Tiku
Chun Kew
Adam Antebi
ResearchOpen Access06 Sept 2018
Nature Communications

Volume: 9, P: 1-10
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Microbes exploit death-induced nutrient release by gut epithelial cells

Intestinal microorganisms exploit nutrients released by apoptotic gut epithelial cells for growth.

Christopher J. Anderson
Christopher B. Medina
Kodi S. Ravichandran
Research04 Aug 2021
Nature

Volume: 596, P: 262-267
Drugging the efferocytosis process: concepts and opportunities

Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infections. Here, Mehrotra and Ravichandran discuss the mechanisms of efferocytosis and the role of this physiological process in disease, and assess strategies and agents for therapeutic intervention.

Parul Mehrotra
Kodi S. Ravichandran
Reviews01 Jun 2022
Nature Reviews Drug Discovery

Volume: 21, P: 601-620
Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend

Arora et al. present AgeXtend, an explainable artificial intelligence-based platform that leverages bioactivity data to predict geroprotectors. They validate potential geroprotectors identified using this platform in yeast, worm and senescence assays.

Sakshi Arora
Aayushi Mittal
Gaurav Ahuja
Research03 Dec 2024
Nature Aging

Volume: 5, P: 144-161
Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism

Shilpa V. Jamwal
Parul Mehrotra
Kanury V.S. Rao
ResearchOpen Access16 Mar 2016
Scientific Reports

Volume: 6, P: 1-9