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Showing 1–5 of 5 results

Advanced filters: Author: Pascal Mäser Clear advanced filters

A new class of anthelmintics effective against drug-resistant nematodes

The discovery of a new chemical class of anthelmintics that seem to act through a novel mechanism is reported. These small molecules are efficacious against various livestock pathogenic-nematode species.

Ronald Kaminsky
Pierre Ducray
Pascal Mäser
Research13 Mar 2008
Nature

Volume: 452, P: 176-180
Structure of trypanosome coat protein VSGsur and function in suramin resistance

The co-crystal structure of VSGsur with the trypanocidal compound suramin directly links the binding of the drug to the resistance phenotype displayed by strains of Trypanosoma brucei expressing VSGsur. Therefore, VSGs can have a function beyond that of antigenic variation.

Johan Zeelen
Monique van Straaten
C. Erec Stebbins
Research18 Jan 2021
Nature Microbiology

Volume: 6, P: 392-400
A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes

Tanja Wenzler
Gabriela Schumann Burkard
Reto Brun
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries

Xue Li Guan
Pascal Mäser
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes

Michael E. Steinmann
Remo S. Schmidt
Erwin Sigel
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-10