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Showing 1–5 of 5 results
Advanced filters: Author: Pascale Zwicky Clear advanced filters

  • During development, blood is generated in the yolk sac by differentiation of haemato-endothelial mesoderm into haematopoietic progenitors. Using CRISPR-Cas9 screens, the authors identify Etv2, Smad1, Ldb1, Six4 and Zbtb7b as regulators of haemato-endothelial mesoderm commitment. Lack of these regulators gave rise to mesodermal subsets with a defined lineage differentiation bias.

    • Michael Teske
    • Tobias Wertheimer
    • Nina Schmolka
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • IL-23 promotes tumor growth in preclinical cancer models and correlates with adverse clinical outcomes. Here, Becher and colleagues find that IL-23 produced by tumor-associated macrophages stabilizes Treg cell identity, promoting immunosuppression and tumor growth.

    • Tobias Wertheimer
    • Pascale Zwicky
    • Burkhard Becher
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 512-524

  • Greter and colleagues identify a population of CD11c+F4/80+CD64+MHCII+CX3CR1+ macrophages in the mouse mammary gland that is induced by lactation and resembles several subsets of macrophages detected in human milk.

    • Dilay Cansever
    • Ekaterina Petrova
    • Melanie Greter
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 1098-1109