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Showing 1–10 of 10 results
Advanced filters: Author: Pasquale Maffia Clear advanced filters

  • Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis.

    • Mohsen Shoaran
    • Pasquale Maffia
    Research Highlights
    Nature Reviews Cardiology
    Volume: 21, P: 442

  • A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers.

    • Simon D. Harding
    • Elena Faccenda
    • Jamie A. Davies
    Research Highlights
    Nature Reviews Immunology
    Volume: 18, P: 729

  • This study reveals that prion protein (PrP) promotes copper toxicity in Wilson disease by facilitating copper endocytosis. The authors demonstrate that suppressing PrP reduces copper overload and liver damage, offering a potential therapeutic strategy for this fatal inherited disorder.

    • Raffaella Petruzzelli
    • Federico Catalano
    • Roman S. Polishchuk
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Gene expression, alternative splicing and DNA methylation profiles from human kidney samples provide insights into the effects of common variants influencing blood pressure. Mendelian randomization uncovers the effects of blood pressure on renal outcomes.

    • James M. Eales
    • Xiao Jiang
    • Maciej Tomaszewski
    Research
    Nature Genetics
    Volume: 53, P: 630-637

  • In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment of atherosclerotic cardiovascular disease.

    • Pasquale Maffia
    • Claudio Mauro
    • Claudia Kemper
    Reviews
    Nature Reviews Cardiology
    Volume: 21, P: 743-761

  • In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

    • Luca Liberale
    • Simon Tual-Chalot
    • Konstantinos Stellos
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 577-605

  • In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, which can help to identify new targets for therapeutic interventions.

    • Tomasz J. Guzik
    • Ryszard Nosalski
    • Grant R. Drummond
    Reviews
    Nature Reviews Cardiology
    Volume: 21, P: 396-416