Nature Search

Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysis

Alström syndrome (AöS) is a rare genetic disorder characterized by metabolic problems. Here, the authors show that in AöS models, defects in cilia and autophagy lead to ACBP accumulation, which drives obesity. An anti-ACBP antibody reduces weight gain and metabolic dysfunction, highlighting ACBP as a therapeutic target for this ciliopathy.

Yaiza Corral Nieto
Amanda Gabrielly Fernández Pereira
José Manuel Bravo-San Pedro
ResearchOpen Access09 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Author Correction: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Juan Ignacio Jiménez-Loygorri
Beatriz Villarejo-Zori
Patricia Boya
Amendments and CorrectionsOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Dysregulated autophagy and mitochondrial function are two well-described hallmarks of aging. Here, the authors describe an unexpected age-associated upregulation of mitophagy in response to neuroinflammation triggered by leaked mtDNA.

Juan Ignacio Jiménez-Loygorri
Beatriz Villarejo-Zori
Patricia Boya
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Emerging regulation and functions of autophagy

Autophagy maintains cell, tissue and organism homeostasis through degradation. Codogno, Boya and Reggiori review recent data that have uncovered unexpected functions of autophagy, such as regulation of metabolism, membrane transport and modulation of host defenses.

Patricia Boya
Fulvio Reggiori
Patrice Codogno
Reviews01 Jul 2013
Nature Cell Biology

Volume: 15, P: 713-720
Lipid dismantling of lens organelles for clear vision

In the eye, the transparent lens focuses light on the retina. This transparency is achieved during lens development by a newly identified mechanism — whole organelles are destroyed by the degradation of their lipid membranes.

Patricia Boya
News & Views14 Apr 2021
Nature

Volume: 592, P: 509-510
Erratum: Emerging regulation and functions of autophagy

Patricia Boya
Fulvio Reggiori
Patrice Codogno
Amendments and Corrections01 Aug 2013
Nature Cell Biology

Volume: 15, P: 1017
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1. They demonstrate the protective effect of boosting chaperone-mediated autophagy against retinal degeneration.

Raquel Gomez-Sintes
Qisheng Xin
Ana Maria Cuervo
ResearchOpen Access21 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine

Patricia Boya
Rosa-Ana Gonzalez-Polo
Guido Kroemer
Research17 Jun 2003
Oncogene

Volume: 22, P: 3927-3936
Recycling in sight

Vision requires the continuous recycling of photobleached pigments. An atypical form of a degradative pathway called autophagy seems to participate in this process in retinal pigment epithelial cells.

Patricia Boya
Patrice Codogno
News & Views04 Sept 2013
Nature

Volume: 501, P: 40-42
Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos

Beatriz Villarejo-Zori
Juan Zapata-Muñoz
Patricia Boya
ResearchOpen Access19 May 2025
Cell Death & Disease

Volume: 16, P: 1-13
Women in Autophagy: an initiative to promote gender parity in science

Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in Autophagy network promote the careers of these underrepresented groups with a range of free, year-round scientific, mentoring and networking activities for all scientists.

Mericka McCabe
Patricia Boya
Ana Maria Cuervo
Comments & Opinion02 Dec 2024
Nature Cell Biology

Volume: 26, P: 2009-2012
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Malumbres and colleagues reveal that mitotic arrest is accompanied by reduced mitochondrial mass and oxidative respiration resulting in activation of AMPK and induction of glycolysis to promote cell survival.

Elena Doménech
Carolina Maestre
Marcos Malumbres
Research31 Aug 2015
Nature Cell Biology

Volume: 17, P: 1304-1316
Age related retinal Ganglion cell susceptibility in context of autophagy deficiency

Katharina Bell
Ines Rosignol
Patricia Boya
ResearchOpen Access17 Apr 2020
Cell Death Discovery

Volume: 6, P: 1-13
Why autophagy is good for retinal ganglion cells?

P Boya
Research16 Dec 2016
Eye

Volume: 31, P: 185-190
HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice

Marijana Samardzija
Andrea Corna
Dragana Trifunović
ResearchOpen Access06 Nov 2020
Cell Death & Differentiation

Volume: 28, P: 1317-1332
p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics

Álvaro Sahún-Español
Cristina Clemente
Alicia G. Arroyo
ResearchOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X_L

Helena LA Vieira
Patricia Boya
Guido Kroemer
Research22 Mar 2002
Oncogene

Volume: 21, P: 1963-1977
Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

N Rodríguez-Muela
A M Hernández-Pinto
P Boya
Research12 Dec 2014
Cell Death & Differentiation

Volume: 22, P: 476-487
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

Patricia Boya
Maria Celia Morales
Guido Kroemer
Research18 Sept 2003
Oncogene

Volume: 22, P: 6220-6230
Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

Álvaro F Fernández
Clea Bárcena
Guillermo Mariño
ResearchOpen Access03 Aug 2017
Cell Death & Disease

Volume: 8, P: e2970
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi
Ilio Vitale
Guido Kroemer
ReviewsOpen Access23 Jan 2018
Cell Death & Differentiation

Volume: 25, P: 486-541

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