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Showing 1–10 of 10 results
Advanced filters: Author: Patrick C. A. van der Wel Clear advanced filters

  • An integrated structural biology approach encompassing solid-state NMR and molecular dynamics simulations was implemented to obtain an atomic view of the ordered polyglutamine core and fuzzy coat of the amyloid-like protein aggregates implicated in Huntington’s disease.

    • Mahdi Bagherpoor Helabad
    • Irina Matlahov
    • Markus S. Miettinen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Polydopamine is a biomimetic self-adherent polymer, which can be easily deposited on a wide variety of materials but the polymerization mechanism and the key intermediate species formed during the deposition process are still controversial. Here, the authors report a systematic investigation of polydopamine formation on halloysite nanotubes.

    • Hamoon Hemmatpour
    • Oreste De Luca
    • Petra Rudolf
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 DnaJB8. They identify an intra-oligomer DnaJB8 interaction between the N-terminal J-Domain and the C-terminal domain that occludes the J-Domain surface that binds Hsp70 and propose a model for DnaJB8-Hsp70 recruitment.

    • Bryan D. Ryder
    • Irina Matlahov
    • Lukasz A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • In this study, Kagan et al. highlight the relevance of adequate cardiolipin homeostasis by offering mechanistic insight into the pathogenesis of Barth syndrome. The study shows how altered accumulation of mono-lyso-cardiolipin, one of the derivatives of the mitochondrial lipid cardiolipin, forms an anomalous peroxidase complex with cytochrome c, thus leading to increased oxidation of polyunsaturated phospholipids.

    • Valerian E. Kagan
    • Yulia Y. Tyurina
    • Miriam L. Greenberg
    Research
    Nature Metabolism
    Volume: 5, P: 2184-2205

  • The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.

    • Andrea Strakova
    • Thomas J. Nicholls
    • Elizabeth P. Murchison
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

    • Ginevra Doglioni
    • Juan Fernández-García
    • Sarah-Maria Fendt
    Research
    Nature
    Volume: 638, P: 244-250

  • Huntington's disease is caused by a polyglutamine stretch expansion in the first exon of huntingtin. Here, the authors use infrared spectroscopy and solid-state NMR and show that polymorphic huntingtin exon1 fibres differ in their flanking regions but not their core polyglutamine amyloid structures.

    • Hsiang-Kai Lin
    • Jennifer C. Boatz
    • Patrick C. A. van der Wel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Aggregation of eye lens proteins leads to cataracts, a major cause of blindness. Here the authors use solid state NMR to probe the structure of γD-crystallin eye lens proteins aggregates, which are found to retain a native-like conformation.

    • Jennifer C. Boatz
    • Matthew J. Whitley
    • Patrick C. A. van der Wel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Spider silks are attractive candidates as biomaterials due to their biocompatibility, biodegradability and mechanical properties, but synthesizing their protein constituents remains challenging. Here, the authors develop a minimal synthetic mimic that undergoes complex coacervation and supramolecular crosslinking, revealing spider silk-like behaviors such as liquid–liquid phase separation, secondary structure formation, and aging.

    • Armin Amirsadeghi
    • Raffaella Parlato
    • Guillermo Monreal Santiago
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-14