Nature Search

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1314-1332
Non-invasive in vivo sensing of bacterial implant infection using catalytically-optimised gold nanocluster-loaded liposomes for urinary readout

Implant-associated infections with Staphylococcus aureus pose serious clinical challenges. Here, the authors develop a biosensor based on toxin-responsive liposomes encapsulating gold nanoclusters, providing a non-invasive, colourimetric diagnostic tool for bacterial infection detection with urinary readout.

Kaili Chen
Adrian Najer
Molly M. Stevens
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting

Label-free surface-enhanced Raman spectroscopy is an emergent method for the detection and discrimination of biological analytes. Here, the authors describe SERS sensors with arrayed mildly-selective surface chemistries to give a fingerprint based on different interactions for analysing biological samples.

Nayoung Kim
Michael R. Thomas
Molly M. Stevens
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Amendments and Corrections16 Mar 2021
Nature Genetics

Volume: 53, P: 762

Search

Filter By:

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Non-invasive in vivo sensing of bacterial implant infection using catalytically-optimised gold nanocluster-loaded liposomes for urinary readout

Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Search

Quick links