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Showing 1–4 of 4 results
Advanced filters: Author: Patrick G. Burrola Clear advanced filters

  • How microglia sense amyloid plaques in Alzheimer’s disease has remained mysterious. Lemke and colleagues report that TAM receptor kinases are absolutely required for normal microglial recognition of, response to and phagocytosis of Aβ plaques. Surprisingly, TAM-mediated microglial phagocytosis of Aβ material does not constrain, but rather promotes, the formation of dense-core plaques.

    • Youtong Huang
    • Kaisa E. Happonen
    • Greg Lemke
    Research
    Nature Immunology
    Volume: 22, P: 586-594

  • Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.

    • Lawrence Fourgeaud
    • Paqui G. Través
    • Greg Lemke
    Research
    Nature
    Volume: 532, P: 240-244