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Understanding the distribution of energy between electric and magnetic channels of a metamaterial remains elusive. Decker et al.study the emission of quantum dots into these channels for a split-ring-resonator metamaterial and differentiate the fundamental behaviour of the two modes.

Spaces with negative curvature are difficult to realise and investigate experimentally, but they can be emulated with synthetic matter. Here, the authors show how to do this using an electric circuit network, and present a method to characterize and verify the hyperbolic nature of the implemented model.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Described is a high-throughput yeast one-hybrid platform for mapping protein-DNA interactions and a sequence-verified clone collection of Drosophila transcription factors. Also in this issue, Reece-Hoyes et al. report enhanced yeast one-hybrid assays, an alternative system for large-scale protein-DNA interaction screens.

A radio-loud magnetar, XTE J1810–197, has been observed to precess shortly after an X-ray outburst. The precession decayed over the subsequent few months, which probably rules out freely precessing magnetars as the source of the fast radio bursts.

Deep learning approaches can show excellent performance but still have limited practical use if they learn to predict based on confounding factors in a dataset, for instance text labels in the corner of images. By using an explanatory interactive learning approach, with a human expert in the loop during training, it becomes possible to avoid predictions based on confounding factors.

Direct detection of gas phase water from the disk of V883 Ori indicates that disks directly inherit water from the star-forming cloud that becomes incorporated into large icy bodies without notable chemical alteration.

The Consistent Histories formalism can solve paradoxes in quantum mechanics, but finding such consistent sets of histories requires a computational overhead which is exponential in the problem’s size. Here, the authors report a variational hybrid algorithm solving this problem using polynomial resources.

An end-to-end quantum error correction protocol that implements fault-tolerant memory on the basis of a family of low-density parity-check codes shows the possibility of low-overhead fault-tolerant quantum memory within the reach of near-term quantum processors.

X-ray polarimetry observations with the Imaging X-ray Polarimetry Explorer constrain the accretion geometry in an X-ray pulsar and provide evidence for a misalignment of the spin, magnetic and orbital axes in Her X-1.

Reactions at the interface between mineral surfaces and flowing liquids are ubiquitous in nature. Here the authors explore, using surface-specific sum frequency generation spectroscopy and numeric calculations, how the liquid flow affects the charging and dissolution rates leading to flow-dependent charge gradients along the surface.

Techniques for tagging active neurons with high spatiotemporal precision are limited. Here the authors report soma-targeted CalLight (ST-Cal-Light) which selectively converts somatic calcium rise triggered by action potentials into gene expression, and generate a conditional ST-Cal-Light knock-in mouse.

Ceasrine et al. show that a maternal high-fat diet leads to impaired serotonin bioavailability in the male fetal brain by disrupting the placenta–brain axis, which can cause long-lasting behavioural changes in the offspring.

Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Parametrised quantum circuits are a promising hybrid classical-quantum approach, but rigorous results on their effective capabilities are rare. Here, the authors explore the feasibility of training depending on the type of cost functions, showing that local ones are less prone to the barren plateau problem.

Here, the authors utilise cefiderocol, a sideromycin, in complex with colloidal bismuth citrate, to demonstrate antimicrobial efficacy against Pseudomonas aeruginosa in vivo.

Disease signatures in high-dimensional biomedical data are detected with a visualization algorithm.

Reversible DNA inversions found entirely within genes enable increased coding capacity by encoding multiple versions of a protein in bacteria and archaea.

The bispecific molecule tebotelimab, which blocks both PD-1 and LAG-3, is well tolerated as a monotherapy and in combination with the anti-HER-2 antibody margetuximab and elicits encouraging clinical activity in solid tumors with high LAG-3 levels and/or expression of IFN-γ-regulated genes.

This Review discusses quantum optimization, focusing on the potential of exact, approximate and heuristic methods, core algorithmic building blocks, problem classes and benchmarking metrics. The challenges for quantum optimization are considered, and next steps are suggested for progress towards achieving quantum advantage.

In addition to the broken time-reversal symmetry that typifies Chern insulators, twisted bilayer graphene hosts a set of topological states with broken translational symmetry.

The advent of commercial quantum devices has ushered in the era of near-term quantum computing. Variational quantum algorithms are promising candidates to make use of these devices for achieving a practical quantum advantage over classical computers.

Third-party punishment of unfair sharing is a hallmark of a normative concern for fairness in adults. Here, children in Canada, India, Peru, Uganda, USA, and Vanuatu show this same normative concern by punishing peers—sometimes even at personal cost—who have shared unfairly.

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.