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Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures

Nyasha Chambwe
Scott R. Kennedy
Raymond J. Monnat Jr.
ResearchOpen Access21 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Quiescent populations are a likely key source of treatment resistance in glioblastoma. Here, the authors characterize KAT5 as a critical mediator of quiescence and adoption of progenitor-like states.

Anca B. Mihalas
Sonali Arora
Patrick J. Paddison
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-20
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

Ghajar and colleagues report that astrocyte-deposited laminin-211 promotes the quiescence of disseminated tumor cells in the brain, in a manner dependent on the cytoplasmic sequestration of YAP by dystroglycan.

Jinxiang Dai
Patrick J. Cimino
Cyrus M. Ghajar
Research24 Dec 2021
Nature Cancer

Volume: 3, P: 25-42
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

Carlson et al. show that DTCs within the PVN are protected from chemotherapy; targeting interactions between DTCs and the PVN enhances chemosensitivity and prevents bone metastasis.

Patrick Carlson
Arko Dasgupta
Cyrus M. Ghajar
Research21 Jan 2019
Nature Cell Biology

Volume: 21, P: 238-250
N⁶-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

Erythropoiesis can be regulated by transcriptional, epigenetic, and post-transcriptional mechanisms. Here the authors report that N⁶-methyladenosine mRNA methyltransferase complex stimulates erythropoiesis by promoting translation of specific mRNAs.

Daniel A. Kuppers
Sonali Arora
Patrick J. Paddison
ResearchOpen Access10 Oct 2019
Nature Communications

Volume: 10, P: 1-17
A resource for large-scale RNA-interference-based screens in mammals

Patrick J. Paddison
Jose M. Silva
Gregory J. Hannon
Research25 Mar 2004
Nature

Volume: 428, P: 427-431
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF-driven gliomas in vivo and augments PI3K signaling cascades in vitro.

Siobhan S. Pattwell
Sonali Arora
Eric C. Holland
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-14
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

Michael T. Hemann
Jordan S. Fridman
Scott W. Lowe
Research03 Feb 2003
Nature Genetics

Volume: 33, P: 396-400
Synthetic shRNAs as potent RNAi triggers

Despina Siolas
Cara Lerner
Michele A Cleary
Research26 Dec 2004
Nature Biotechnology

Volume: 23, P: 227-231
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis

Michele A Cleary
Kristopher Kilian
Gregory J Hannon
Research18 Nov 2004
Nature Methods

Volume: 1, P: 241-248
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

The 17–92 miRNA cluster promotes tumourigenesis although the identity of the specific miRNA responsible for this effect has been unclear. MiR-19 is sufficient to promote Notch induced T-cell associated leukaemia in vivo and a shRNA screen for genes that phenocopy miR-19 effects identifies PI3-K regulators as miR-19 target genes.

Konstantinos J. Mavrakis
Andrew L. Wolfe
Hans-Guido Wendel
Research28 Feb 2010
Nature Cell Biology

Volume: 12, P: 372-379
Delivery of short hairpin RNAs—triggers of gene silencing—into mouse embryonic stem cells

Christoph Schaniel
Feng Li
Patrick J Paddison
Protocols01 May 2006
Nature Methods

Volume: 3, P: 397-400
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

Tyler E. Miller
Brian B. Liau
Jeremy N. Rich
Research05 Jul 2017
Nature

Volume: 547, P: 355-359
Cloning of short hairpin RNAs for gene knockdown in mammalian cells

Patrick J Paddison
Michele Cleary
Gregory J Hannon
Protocols01 Nov 2004
Nature Methods

Volume: 1, P: 163-167
Second-generation shRNA libraries covering the mouse and human genomes

Jose M Silva
Mamie Z Li
Gregory J Hannon
Research02 Oct 2005
Nature Genetics

Volume: 37, P: 1281-1288

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Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

N⁶-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

A resource for large-scale RNA-interference-based screens in mammals

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

Synthetic shRNAs as potent RNAi triggers

Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

Delivery of short hairpin RNAs—triggers of gene silencing—into mouse embryonic stem cells

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

Cloning of short hairpin RNAs for gene knockdown in mammalian cells

Second-generation shRNA libraries covering the mouse and human genomes

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