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Showing 1–4 of 4 results
Advanced filters: Author: Patrick K. Tumwebaze Clear advanced filters

  • In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.

    • Patrick K. Tumwebaze
    • Melissa D. Conrad
    • Philip J. Rosenthal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.

    • Robert Verity
    • Ozkan Aydemir
    • Jonathan J. Juliano
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito vectors, is safe in rats, and pharmacokinetic-pharmacodynamic modeling informs about a potential oral human dosing regimen.

    • Laura E. de Vries
    • Patrick A. M. Jansen
    • Koen J. Dechering
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16