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Silencing lipid catabolism determines longevity in response to fasting

The relative contribution of lipid catabolism on fasting-induced longevity was unknown. Authors showed lifespan extension from fasting depend on silencing lipid catabolism upon nutrient replenishment through phosphorylation of NHR-49 by KIN-19.

Lexus Tatge
Juhee Kim
Peter M. Douglas
ResearchOpen Access22 Jan 2026
Nature Communications

P: 1-22
Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy

Neurons deploy diverse adaptive strategies to ensure survival and neurotransmission amid cellular stress. Here authors show that stressed dopaminergic neurons actively induce a state of transmissive dormancy and appear to prioritize viability over functionality.

Kielen R. Zuurbier
Rene Solano Fonseca
Peter M. Douglas
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

The effects of vaccines on human dendritic cells (DCs) are incompletely understood. Here the authors build a transcriptional modular network based on in vitroinfection of human DCs and apply it for the characterization of the DC response to 13 different vaccines.

Romain Banchereau
Nicole Baldwin
Virginia Pascual
ResearchOpen Access22 Oct 2014
Nature Communications

Volume: 5, P: 1-14
Intracellular lipid surveillance by small G protein geranylgeranylation

In Caenorhabditis elegans, geranylgeranyl conjugation to RAB-11.1 acts as a lipid sensor to regulate nutrient uptake and lipid metabolism in response to metabolic demand.

Abigail Watterson
Lexus Tatge
Peter M. Douglas
Research18 May 2022
Nature

Volume: 605, P: 736-740

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Silencing lipid catabolism determines longevity in response to fasting

Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy

Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

Intracellular lipid surveillance by small G protein geranylgeranylation

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