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Showing 1–30 of 30 results
Advanced filters: Author: Patrick R. Batista Clear advanced filters

  • Glioblastoma (GBM) is characterized by a high degree of heterogeneity and plasticity due to interplay with neural developmental programs. Here, the authors develop a model of GBM by introducing sequential oncogenic mutations in human neural stem cells and using this, identify INSM1 as a driver of a neural progenitor gene network promoting tumorigenesis.

    • Patrick A. DeSouza
    • Matthew Ishahak
    • Albert H. Kim
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to be highly robust, suggestive of network-level computational mechanisms.

    • Emily R. Oby
    • Alan D. Degenhart
    • Aaron P. Batista
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 383-393

  • Using a combination of MD simulations and NMR, the authors investigate how temperature affects allostery in imidazole glycerol phosphate synthase (IGPS), revealing that increase of temperature triggers local amino acid dynamics and providing insights into mechanism of allosteric regulation.

    • Federica Maschietto
    • Uriel N. Morzan
    • Victor S. Batista
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

    • James E. D. Thaventhiran
    • Hana Lango Allen
    • Kenneth G. C. Smith
    Research
    Nature
    Volume: 583, P: 90-95

  • A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

    • Jeffrey V. Lazarus
    • Diana Romero
    • Anne Øvrehus
    ResearchOpen Access
    Nature
    Volume: 611, P: 332-345

  • Hennig et al. study how changes in internal state interact with learning in primates. They report stereotyped activity fluctuations in the motor cortex that reflect the animal’s level of engagement and predict how quickly the animals learned.

    • Jay A. Hennig
    • Emily R. Oby
    • Byron M. Yu
    Research
    Nature Neuroscience
    Volume: 24, P: 727-736

  • Fred Wright, Patrick Sullivan and colleagues present the results of a large expression QTL study of peripheral blood using a classic twin design with follow-up replication in independent samples. Their results enable a more precise estimate of the heritability of gene expression and provide a useful resource for exploring the genetic control of transcription.

    • Fred A Wright
    • Patrick F Sullivan
    • Dorret I Boomsma
    Research
    Nature Genetics
    Volume: 46, P: 430-437

  • Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

    • Torben Schiffner
    • Ivy Phung
    • William R. Schief
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1073-1082

  • Application of an electrical field to Geobacter sulfurreducens biofilms stimulates production of OmcZ nanowires, which undergo a pH-induced conformational switch that causes increased stiffness and conductivity due to enhanced heme group π-stacking.

    • Sibel Ebru Yalcin
    • J. Patrick O’Brien
    • Nikhil S. Malvankar
    Research
    Nature Chemical Biology
    Volume: 16, P: 1136-1142

  • During learning, the new patterns of neural population activity that develop are constrained by the existing network structure so that certain patterns can be generated more readily than others.

    • Patrick T. Sadtler
    • Kristin M. Quick
    • Aaron P. Batista
    Research
    Nature
    Volume: 512, P: 423-426

  • Optical pulses can be useful to create and control molecules in higher quantum states. Here the authors use optical pumping to create rotationally excited states of SiO+ molecular ion into super rotor ensemble.

    • Ivan O. Antonov
    • Patrick R. Stollenwerk
    • Brian C. Odom
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Bacterial hairs called pili become highly-conductive electric wires upon addition of both natural and synthetic amino acids conjugated with gold nanoparticles. Here the authors use computationally-guided ordering further increasing their conductivity, thus yielding genetically-programmable materials.

    • Daniel Mark Shapiro
    • Gunasheil Mandava
    • Farren J. Isaacs
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

    • Bin Zhou
    • Kate E. Sheffer
    • Majid Ezzati
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2885-2901

  • Learning is ubiquitous in everyday life, yet it is unclear how neurons change their activity together during learning. Golub and colleagues show that short-term learning relies on a fixed neural repertoire, which limits behavioral improvement.

    • Matthew D. Golub
    • Patrick T. Sadtler
    • Byron M. Yu
    Research
    Nature Neuroscience
    Volume: 21, P: 607-616

  • Leptomeningeal metastatic disease (LMD) arises secondary to the metastatic dissemination of cancer cells into the leptomeninges and cerebrospinal fluid. Novel therapies against systemic disease have not yet translated into improved outcomes for patients with LMD, in whom median survival after diagnosis remains at 2–6 months. The authors of this Review, a multidisciplinary group of experts, describe the emerging evidence and areas of active investigation in LMD and provide directed recommendations for future research.

    • Ahmad Ozair
    • Hannah Wilding
    • Alireza Mansouri
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 134-154

  • Although the photogeneration yield spectrum is a key property for photoabsorbers in photovoltaic and photoelectrochemical cells, its characterization remains challenging. An empirical method to extract this parameter through quantum efficiency measurements of ultrathin films is proposed.

    • Daniel A. Grave
    • David S. Ellis
    • Avner Rothschild
    Research
    Nature Materials
    Volume: 20, P: 833-840

  • Fernández Villalobos, Marsall et al. analyzed seroprevalence and antibody responses to SARS-CoV-2 variants and endemic coronaviruses in Colombian children from urban and indigenous populations. They find high SARS-CoV-2 seroprevalence with comparable antibody titers but low neutralizing capacity and limited cross-protective immunity.

    • Nathalie Verónica Fernández Villalobos
    • Patrick Marsall
    • Simone Kann
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-8

  • Global carbon budgets reveal that inland waters emit substantial amounts of carbon, which is believed to originate from the terrestrial biosphere; however, here the carbon emitted from the Amazon River system is shown to originate from temporary wetlands in the flooded area itself, such as flooded forests.

    • Gwenaël Abril
    • Jean-Michel Martinez
    • Fabio Roland
    Research
    Nature
    Volume: 505, P: 395-398

  • UniProt continues to support the ongoing process of making scientific data FAIR. Here we contribute to this process with a FAIRness assessment of our UniProtKB dataset followed by a critical reflection on the challenges and future directions of the adoption and validation of the FAIR principles and metrics.

    • Leyla Garcia
    • Jerven Bolleman
    • Jian Zhang
    Comments & OpinionOpen Access
    Scientific Data
    Volume: 6, P: 1-4