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Showing 1–16 of 16 results
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  • Angueira et al. identify distinct populations of thermogenic perivascular adipocyte progenitors from thoracic adipose tissue in mice and humans.

    • Anthony R. Angueira
    • Alexander P. Sakers
    • Patrick Seale
    Research
    Nature Metabolism
    Volume: 3, P: 469-484

  • Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques.

    • Josephine M. E. Tan
    • Lan Cheng
    • Patrick Seale
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1573-1588

  • Lundgren et al. show that in response to transient cold exposure, a distinct subpopulation of brown adipocytes carries out a lipogenic response involving production of acylcarnitines, which enables an improved thermogenic response to secondary cold exposure.

    • Patrick Lundgren
    • Prateek V. Sharma
    • Christoph A. Thaiss
    Research
    Nature Metabolism
    Volume: 5, P: 1691-1705

  • Here it is shown that PRDM16, a zinc finger protein that controls the switch from myoblastic precursors to brown fat cells, works together with C/EBP-β and that expression of this transcriptional unit is sufficient to induce a fully functional brown fat program in naive fibroblasts. Transplantation of such fibroblasts into mice creates a brown fat pad that acts as a sink for glucose.

    • Shingo Kajimura
    • Patrick Seale
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 460, P: 1154-1158

  • Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.

    • Suzanne N. Shapira
    • Patrick Seale
    News & Views
    Nature Cell Biology
    Volume: 19, P: 1006-1007

  • Brown adipocytes (which reside in brown adipose tissue) and beige adipocytes (which develop in white adipose tissue in response to cold) expend energy to produce heat and are therefore important in regulating body temperature and body weight. Recent studies provide insights into the developmental origins of brown and beige adipocytes and into the regulation of their differentiation and function.

    • Wenshan Wang
    • Patrick Seale
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 691-702

  • There is much interest in brown and beige adipocytes, as their thermogenic activities can suppress weight gain and metabolic disease in rodent models. The authors review recent data that have provided new insights into the development and biology of brown and beige adipocytes and critically assess the possibilities for manipulating these cells to combat obesity and its associated diseases.

    • Matthew Harms
    • Patrick Seale
    Reviews
    Nature Medicine
    Volume: 19, P: 1252-1263

  • An understanding of how fat cells (adipocytes) develop will contribute to our understanding of obesity. The differentiation of committed preadipocytes into adipocytes is known to be controlled by PPARγ and several other transcription factors. But what turns a cell into a preadipocyte? Here, the zinc-finger protein Zfp423 is identified as a transcriptional regulator of preadipocyte determination.

    • Rana K. Gupta
    • Zoltan Arany
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 464, P: 619-623

  • Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

    • Jonathan R. Brestoff
    • Brian S. Kim
    • David Artis
    Research
    Nature
    Volume: 519, P: 242-246