Harre et al. analyze serum lipids from patients with NSCLC and test how cholesterol- or ω−3 PUFA–enriched diets affect tumor growth and immunity in mouse models, with or without PD-1 therapy. They find that cholesterol drives tumor progression and immune suppression, while ω−3 PUFAs reduce tumor burden and improve PD-1 efficacy
- Philipp Harre
- Katja Hohenberger
- Susetta Finotto
