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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Patrick-Simon Welz
Andy Wullaert
Manolis Pasparakis
Research31 Jul 2011
Nature

Volume: 477, P: 330-334
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback

Circadian clocks both instruct and follow the epigenome. New data reveal that the core-clock PERIOD complex shapes genomic H2A.Z landscapes. H2A.Z, in turn, plays an essential role in rhythm generation by regulating BMAL1 stability.

Kevin Tartour
Francesca Andriani
Kiran Padmanabhan
Research23 May 2022
Nature Structural & Molecular Biology

Volume: 29, P: 549-562
The tumour suppressor CYLD regulates the p53 DNA damage response

CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in response to DNA damage.

Vanesa Fernández-Majada
Patrick-Simon Welz
Manolis Pasparakis
ResearchOpen Access26 Aug 2016
Nature Communications

Volume: 7, P: 1-14