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Showing 1–5 of 5 results
Advanced filters: Author: Paul Adrian Ginno Clear advanced filters

  • Local activity of the DNA methylation machinery remains poorly understood. Here, the authors present a theoretical and experimental framework to infer methylation and demethylation rates at genome scale in mouse embryonic stem cells, finding that maintenance methylation activity is reduced at transcription factor binding sites, while methylation turnover is elevated in transcribed gene bodies.

    • Paul Adrian Ginno
    • Dimos Gaidatzis
    • Dirk Schübeler
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • SARS-CoV-2 antigen tests are commonly used point-of-care tests and provide rapid results but lack sensitivity. Here, the authors present a new point-of-care approach for COVID-19 diagnosis, “ADESSO”, which outperforms antigen tests on clinical samples and can be quickly adapted for different variants.

    • Beatrice Casati
    • Joseph Peter Verdi
    • Riccardo Pecori
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • A single-cell-based approach allows the daughters of a damaged cell to be separately tracked following single mitotic events. This technique highlights the different ways in which ultraviolet light and reactive oxygen species cause mutagenesis.

    • Paul Adrian Ginno
    • Helena Borgers
    • Duncan T. Odom
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 913-924

  • Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.

    • Paul Adrian Ginno
    • Lukas Burger
    • Dirk Schübeler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The relationship between DNA methylation and transcription factor binding was studied across the genome in mouse embryonic stem cells-the study reveals that the transcription factor NRF1 is methylation-sensitive and how physiological binding of NRF1 relies on local removal of DNA methylation.

    • Silvia Domcke
    • Anaïs Flore Bardet
    • Dirk Schübeler
    Research
    Nature
    Volume: 528, P: 575-579