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Showing 1–6 of 6 results
Advanced filters: Author: Paul F. Gugger Clear advanced filters

  • The genus Quercus (oaks) has diversified into over 450 species which often play dominant roles in the ecosystems in which they occur. Here the authors present a genome and methylome for a California endemic oak, Quercus lobata, and describe features relevant to its evolutionary success.

    • Victoria L. Sork
    • Shawn J. Cokus
    • Steven L. Salzberg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • We use a whole-cell accumulation assay to assess the ability of non-antibiotic, structurally diverse small molecules to accumulate in Pseudomonas aeruginosa, with potential application in developing drugs to target this pathogen.

    • Emily J. Geddes
    • Morgan K. Gugger
    • Paul J. Hergenrother
    Research
    Nature
    Volume: 624, P: 145-153

  • Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

    • Michelle A. Schorn
    • Stefan Verhoeven
    • Justin J. J. van der Hooft
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 17, P: 363-368

  • In this paper, single-nucleus RNA sequencing was performed to provide a resource of cell-specific niches in the murine ALS model spinal cord at peri-symptomatic onset stage of disease. The data suggest that dysfunctional neuronal-glial communication occurs prior to disease onset, which is partially recapitulated in human post-mortem ALS spinal cord tissue.

    • Michael MacLean
    • Raquel López-Díez
    • Ann Marie Schmidt
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-16