Nature Search

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading

Lipid particles loaded with RNA coding for tumour-unspecific antigens can enhance early responses of type-I interferons, mediating the success of immune checkpoint inhibitors as well as epitope spreading.

Sadeem Qdaisat
Brandon Wummer
Elias J. Sayour
Research18 Jul 2025
Nature Biomedical Engineering

Volume: 9, P: 1437-1452
Clonal vaccinia virus grown in cell culture as a new smallpox vaccine

Richard Weltzin
Jian Liu
Thomas P Monath
Research17 Aug 2003
Nature Medicine

Volume: 9, P: 1125-1130
Discrepancies between Micellar Molecular Weights by Number-Average and Weight-Average Methods

PAUL BECHER
Research08 May 1965
Nature

Volume: 206, P: 611-613
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type specific.

Jennifer Karin Ocasio
Benjamin Babcock
Timothy R. Gershon
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-17
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
A monocyte–leptin–angiogenesis pathway critical for repair post-infection

Monocytes recruited to skin infection are not involved in bacterial clearance but instead regulate local angiogenesis and healing.

Rachel M. Kratofil
Hanjoo B. Shim
Paul Kubes
Research10 Aug 2022
Nature

Volume: 609, P: 166-173
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition the microenvironment and promote anti-tumor immunity.

Giulia Agliardi
Anna Rita Liuzzi
Burkhard Becher
ResearchOpen Access19 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Molecular and genetic damage in humans from environmental pollution in Poland

Frederica P. Perera
Kari Hemminki
Mieczyslaw Chorazy
Research19 Nov 1992
Nature

Volume: 360, P: 256-258
Chemical gradients in automotive Cu-SSZ-13 catalysts for NO_x removal revealed by operando X-ray spectrotomography

Obtaining spatially resolved spectroscopic information for catalysts under working conditions remains challenging. Here, an approach that combines X-ray absorption spectroscopy with microtomography is introduced and showcased for the selective catalytic reduction of NO_x with ammonia over a Cu-SSZ-13 washcoated monolith catalyst.

Johannes Becher
Dario Ferreira Sanchez
Thomas L. Sheppard
Research14 Dec 2020
Nature Catalysis

Volume: 4, P: 46-53
Sensing of mammalian IL-17A regulates fungal adaptation and virulence

It is unclear whether pathogens can advantageously exploit the host's immune response. UsingCandida albicans, the authors show that host IL-17A binds to the fungi and induces nutrient starvation and autophagy, which eventually leads to enhanced biofilm formation and resistance to the hosts' defence.

Teresa Zelante
Rossana G. Iannitti
Luigina Romani
Research21 Feb 2012
Nature Communications

Volume: 3, P: 1-10
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein pathway may be a therapeutic target in these tumours.

Christine M. Hoeman
Francisco J. Cordero
Oren J. Becher
ResearchOpen Access04 Mar 2019
Nature Communications

Volume: 10, P: 1-15
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Haoyu Zhang
Thomas U. Ahearn
Montserrat García-Closas
Research18 May 2020
Nature Genetics

Volume: 52, P: 572-581
Observation of rare-earth segregation in silicon nitride ceramics at subnanometre dimensions

Naoya Shibata
Stephen J. Pennycook
Paul F. Becher
Research15 Apr 2004
Nature

Volume: 428, P: 730-733
3D imaging of the human temporal bone by X-ray phase-contrast tomography

Jannis J. Schaeper
Paul Tafforeau
Tim Salditt
ResearchOpen Access20 May 2025
npj Imaging

Volume: 3, P: 1-11
Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

Streptomyces bacteria make volatile compounds such as geosmin and 2-methylisoborneol that attract springtails to bacterial colonies. The soil arthropods feed on the bacteria and help to disseminate spores via faecal pellets and through adherence to their surface.

Paul G. Becher
Vasiliki Verschut
Klas Flärdh
Research06 Apr 2020
Nature Microbiology

Volume: 5, P: 821-829
Development of a single-center quality bundle to prevent sudden unexpected postnatal collapse

David A. Paul
Dawn Johnson
Stephen A. Pearlman
Research14 May 2019
Journal of Perinatology

Volume: 39, P: 1008-1013
Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism

Observations of recent or dynamic transitions between parasitism and mutualism are scarce. Here, Flórezet al. provide evidence that Burkholderia gladiolibacteria can protect the eggs of herbivorous beetles by producing antimicrobial compounds, while retaining their ancestral ability to infect plants.

Laura V. Flórez
Kirstin Scherlach
Martin Kaltenpoth
ResearchOpen Access28 Apr 2017
Nature Communications

Volume: 8, P: 1-9
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Meta-analysis of three large whole-exome sequencing datasets highlights protein-truncating and rare missense variants associated with breast cancer susceptibility.

Naomi Wilcox
Martine Dumont
Jacques Simard
ResearchOpen Access17 Aug 2023
Nature Genetics

Volume: 55, P: 1435-1439
Love makes smell blind: mating suppresses pheromone attraction in Drosophila females via Or65a olfactory neurons

Sébastien Lebreton
Veit Grabe
Peter Witzgall
ResearchOpen Access19 Nov 2014
Scientific Reports

Volume: 4, P: 1-6
Flow-induced oscillations of vocal-fold replicas with tuned extensibility and material properties

Paul Luizard
Lucie Bailly
Nathalie Henrich Bernardoni
ResearchOpen Access19 Dec 2023
Scientific Reports

Volume: 13, P: 1-19
Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules

Matthew P Fletcher
Stephen P Diggle
Paul Williams
Protocols17 May 2007
Nature Protocols

Volume: 2, P: 1254-1262
Meteoric smoke fallout over the Holocene epoch revealed by iridium and platinum in Greenland ice

Paolo Gabrielli
Carlo Barbante
Claude F. Boutron
Research23 Dec 2004
Nature

Volume: 432, P: 1011-1014
Brown adipose tissue is associated with cardiometabolic health

Retrospective analysis of ¹⁸F-FDG PET/CT scans from over 50,000 patients reveals correlations between presence of brown adipose tissue and lower odds of having cardiometabolic conditions, such as type 2 diabetes, cardiovascular disease and hypertension.

Tobias Becher
Srikanth Palanisamy
Paul Cohen
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 58-65
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

The study describes the use of integrative approaches to search for candidate therapeutic targets for DIPG, and the identification of an HDAC inhibitor as a potential treatment strategy

Catherine S Grasso
Yujie Tang
Michelle Monje
Research04 May 2015
Nature Medicine

Volume: 21, P: 555-559
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

A chemoproteomics approach utilizing the thermal shift assay and quantitative MS resulted in the identification of phenylalanine hydroxylase as an off-target of the histone deacetylase inhibitor panobinostat.

Isabelle Becher
Thilo Werner
Mikhail M Savitski
Research26 Sept 2016
Nature Chemical Biology

Volume: 12, P: 908-910
The construction of new scientific norms for solving Grand Challenges

Kate Maxwell
Paul Benneworth
ResearchOpen Access01 May 2018
Palgrave Communications

Volume: 4, P: 1-11
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample

Thomas Günther
Ludwig Haas
Nicole Fischer
ResearchOpen Access16 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Jingjing Liu
Wendy J. C. Prager - van der Smissen
Antoinette Hollestelle
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Genetic variability of porcine pegivirus in pigs from Europe and China and insights into tissue tropism

Johanna Kennedy
Vanessa Maria Pfankuche
Christine Baechlein
ResearchOpen Access03 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

Xiaoliang Wang
Pooja Middha Kapoor
Sara Lindström
ResearchOpen Access13 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor

Alexander Postel
Florian Hansmann
Paul Becher
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Unlocking the potential of the terrestrial gastropod species Zootecus insularis as a climate archive for arid regions

Katharina E. Schmitt
Lucas Proctor
Bernd R. Schöne
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence

Tyler J. Rolland
Timothy E. Peterson
Atta Behfar
ResearchOpen Access29 Sept 2022
npj Regenerative Medicine

Volume: 7, P: 1-17
Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

Maria Escala-Garcia
Sander Canisius
Marjanka K. Schmidt
ResearchOpen Access05 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386
Author Correction: Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence

Tyler J. Rolland
Timothy E. Peterson
Atta Behfar
Amendments and CorrectionsOpen Access31 Oct 2022
npj Regenerative Medicine

Volume: 7, P: 1
Pathogenic fungus uses volatiles to entice male flies into fatal matings with infected female cadavers

Andreas Naundrup
Björn Bohman
Henrik H. De Fine Licht
Research13 Jul 2022
The ISME Journal

Volume: 16, P: 2388-2397
Feeding regulates sex pheromone attraction and courtship in Drosophila females

Sébastien Lebreton
Federica Trona
Peter Witzgall
ResearchOpen Access10 Aug 2015
Scientific Reports

Volume: 5, P: 1-11
Guidelines for the welfare and use of animals in cancer research

P Workman
E O Aboagye
S A Eccles
ReviewsOpen Access25 May 2010
British Journal of Cancer

Volume: 102, P: 1555-1577
8.2 ka event North Sea hydrography determined by bivalve shell stable isotope geochemistry

Juan Estrella-Martínez
Philippa L. Ascough
Paul G. Butler
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-9

Search

Filter By:

Search

Quick links