Nature Search

Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs

Toxicity of antibody drug conjugates (ADCs) is often caused by off-target shedding of therapeutic payloads due to linker instability. Here, the authors demonstrate that site-specific ligase-dependent conjugation of therapeutic payloads to engineered trastuzumab via a ring-opening linker improves stability compared to conventional HER2- targeting ADCs.

Lei Huang
Gang Qin
Biyun Wang
ResearchOpen Access03 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Securing interfacial cationic copper for acidic CO₂ reduction to ethylene

Electrochemical CO₂ reduction on copper-based catalysts under acidic conditions offers a promising solution to energy and environmental issues. Our study demonstrates that the yttrium-doped ZrO₂/CuO interface stabilizes Cu⁺ under harsh conditions, thereby enabling high selectivity toward ethylene.

Sifan Wang
Zhecheng Fang
Jie Fu
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Induction of myelinating oligodendrocytes in human cortical spheroids

A method for generating cortical spheroids from human pluripotent stem cells produces maturing oligodendrocytes that can myelinate axons and model myelin disease and drug effects.

Mayur Madhavan
Zachary S. Nevin
Paul J. Tesar
Research25 Jul 2018
Nature Methods

Volume: 15, P: 700-706
Metabolic coupling between soil aerobic methanotrophs and denitrifiers in rice paddy fields

Microbial denitrification in rice paddy fields reduces N use efficiency. Here, the authors use field samples from major rice producing areas in China and identify microbial taxa involved in the metabolic couplings between aerobic CH₄ oxidation and denitrification in rice paddy fields.

Kang-Hua Chen
Jiao Feng
Yu-Rong Liu
ResearchOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1-15
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Paul Dent
Alain Lavoinne
Philip Cohen
Research22 Nov 1990
Nature

Volume: 348, P: 302-308
Manipulating microRNA miR408 enhances both biomass yield and saccharification efficiency in poplar

Modifying plant lignin pathway to enhance saccharification efficiency is often associated with growth penalty. Here, the authors show that overexpression of Pag-miR408 in poplar leads to enhanced saccharification efficiency and growth in both laboratory and field conditions, and laccase genes are the targets of Pag-miR408.

Yayu Guo
Shufang Wang
Jinxing Lin
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-15
Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

Toshiyuki Sakai
Naoko Ohtani
Thaddeus P. Dryja
Research05 Sept 1991
Nature

Volume: 353, P: 83-86
Ultra-fast green hydrogen production from municipal wastewater by an integrated forward osmosis-alkaline water electrolysis system

Green hydrogen production faces increased water risks due to scarce supplies of water. Here, authors develop a modular forward osmosis-water splitting system that utilises wastewater effluent to generate high-purity hydrogen, providing a sustainable solution for water and energy security.

Gabriela Scheibel Cassol
Chii Shang
Li Ling
ResearchOpen Access23 Mar 2024
Nature Communications

Volume: 15, P: 1-10
Heavy-to-light electron transition enabling real-time spectra detection of charged particles by a biocompatible semiconductor

New detector materials are crucial for radiation beam monitoring in dosimeters and X-ray imaging. The authors report a solution-grown biocompatible organic single crystalline semiconductor for real-time spectral detection of charged particles with single-particle sensitivity, X-ray detection and imaging.

Dou Zhao
Ruiling Gao
Yadong Xu
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Gradient matters via filament diameter-adjustable 3D printing

Direct ink writing of complex 3D gradient structures can be challenging due to inherent method limitations. Here, the authors report continuous diameter-adjustable filament by varying printing speed and height and enable extrusion 3D printers to produce complex gradient porous matters.

Huawei Qu
Chongjian Gao
Changshun Ruan
ResearchOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1-13
UbasM: An effective balanced optical clearing method for intact biomedical imaging

Lingling Chen
Guiye Li
Shuangchen Ruan
ResearchOpen Access22 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Plasticity of the gut microbiome of golden snub-nosed monkeys (Rhinopithecus roxellana) in response to seasonal variation in diet

Mingyi Zhang
Xiaochen Wang
Ming Li
ResearchOpen Access22 Aug 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-13
Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

Urine can be used to easily analyse the health of patients. Here, the authors identify proteins in urinary extracellular vesicles that distinguish prostate cancer from benign lesions.

Amanda Khoo
Meinusha Govindarajan
Thomas Kislinger
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells

Interactions between Semaphorin-3A (SEMA3A) and Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 have been shown to affect T cell development. Here the authors investigate how these interactions affect CD8⁺ T cells in tumour immunity, showing that NRP-1, Plexin-A1 and Plexin-A4 are upregulated on T cells allowing tumour derived SEMA3A to inhibit CD8⁺ T cell migration and function.

Mike B. Barnkob
Yale S. Michaels
Vincenzo Cerundolo
ResearchOpen Access12 Apr 2024
Nature Communications

Volume: 15, P: 1-18
A clinically applicable integrative molecular classification of meningiomas

Multi-omics datasets are integrated to generate a unified and clinically informed molecular classification of meningiomas.

Farshad Nassiri
Jeff Liu
Gelareh Zadeh
Research25 Aug 2021
Nature

Volume: 597, P: 119-125
Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach

Yafei Wang
Erik Brodin
Paul Macklin
ResearchOpen Access18 Jan 2021
Scientific Reports

Volume: 11, P: 1-20
Digital twins for predictive oncology will be a paradigm shift for precision cancer care

Tina Hernandez-Boussard
Paul Macklin
Ilya Shmulevich
Correspondence25 Nov 2021
Nature Medicine

Volume: 27, P: 2065-2066
Assessment of a rapid diagnostic test to exclude bacteraemia and effect on clinical decision-making for antimicrobial therapy

Samuel Yui
Georgia Bercades
Peter Wilson
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens

Rishi R. Rawat
Daniel Ruderman
David B. Agus
ResearchOpen Access04 Sept 2018
npj Breast Cancer

Volume: 4, P: 1-7
Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

iGluSnFR variants with improved signal-to-noise ratios and targeting to postsynaptic sites have been developed, enabling the analysis of glutamatergic neurotransmission in vivo as illustrated in the mouse visual and somatosensory cortex.

Abhi Aggarwal
Rui Liu
Kaspar Podgorski
ResearchOpen Access04 May 2023
Nature Methods

Volume: 20, P: 925-934
Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells

Mike B. Barnkob
Yale S. Michaels
Vincenzo Cerundolo
Amendments and CorrectionsOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1
Improving academic mentorship practices

Mentorship from experienced peers critically improves individual career development and satisfaction in academia, but we have little information on how researchers are supported. We identify and recommend strategies for faculty members, departments, institutions and funders to ensure sustained excellence in academic mentorship.

Sarvenaz Sarabipour
Paul Macklin
Natalie M. Niemi
Comments & Opinion06 Jun 2024
Nature Human Behaviour

Volume: 8, P: 1228-1231
Development of catalytic zero-valent iron incorporated PAN catalytic film for efficient degradation of organic matters

Yi Yang
Haowen Lin
J. Paul Chen
ResearchOpen Access13 May 2024
npj Clean Water

Volume: 7, P: 1-10
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Envisioning the future of precision oncology trials

Precision oncology trials based on cancer biomarkers have the potential to improve outcomes by guiding the optimal choice of therapies for patients. For this to be truly achieved, computational methods such as virtual molecular tumor boards, dynamic precision medicine and digital twins are needed to support cohort selection and trial enrollment at scale.

Subha Madhavan
Robert A. Beckman
Paul Macklin
Comments & Opinion04 Jan 2021
Nature Cancer

Volume: 2, P: 9-11
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
The genome of the glasshouse plant noble rhubarb (Rheum nobile) provides a window into alpine adaptation

A high-quality genome assembly and phylogenetic analysis for the glasshouse plant, Rheum nobile, shed light on its evolutionary history and ability to adapt to intensive UV radiation in a low-temperature, alpine environment.

Tao Feng
Boas Pucker
Hang Sun
ResearchOpen Access10 Jul 2023
Communications Biology

Volume: 6, P: 1-15
Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer

Niki Tavakoli
Emma J. Fong
Shannon M. Mumenthaler
ResearchOpen Access28 Jan 2025
npj Systems Biology and Applications

Volume: 11, P: 1-17
Tailings storage facilities, failures and disaster risk

Mine tailings are voluminous and often toxic wastes, whose management is a global safety and sustainability challenge. This Review summarizes the major tailings storage facility disasters and impacts, emphasizing the urgent need for risk reduction approaches for management and policy.

Karen A. Hudson-Edwards
Deanna Kemp
Christopher J. Thomas
Reviews06 Aug 2024
Nature Reviews Earth & Environment

Volume: 5, P: 612-630
A multiscale model of immune surveillance in micrometastases gives insights on cancer patient digital twins

Heber L. Rocha
Boris Aguilar
Paul Macklin
ResearchOpen Access04 Dec 2024
npj Systems Biology and Applications

Volume: 10, P: 1-12
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.

Michael P. Snyder
Shin Lin
James Anderson
ReviewsOpen Access09 Oct 2019
Nature

Volume: 574, P: 187-192
From smoking to lung cancer: the CHRNA5/A3/B4 connection

M R D Improgo
M D Scofield
P D Gardner
Reviews28 Jun 2010
Oncogene

Volume: 29, P: 4874-4884
Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease

Clive Hoggart
Chisato Shimizu
Michael Levin
ResearchOpen Access26 Mar 2021
European Journal of Human Genetics

Volume: 29, P: 1734-1744
Forum on immune digital twins: a meeting report

Reinhard Laubenbacher
Fred Adler
Tjalf Ziemssen
ReviewsOpen Access16 Feb 2024
npj Systems Biology and Applications

Volume: 10, P: 1-8

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