Nature Search

Prediction of outcome from spatial Protein profiling of triple-negative breast cancers

Foroughi Pour et al. developed a segmentation-free method, called SparTile, for analyzing spatial proteomics data. They show relative spatial distance of tumor and myeloid cells is a prognostic marker of survival risk in triple-negative breast cancer patients.

Ali Foroughi pour
Te-Chia Wu
Jeffrey H. Chuang
ResearchOpen Access29 Jan 2026
Communications Medicine

P: 1-11
Mutagenicity of Sarkomycin

YOSHIO NAKAO
YATARO TAZIMA
TADASHI YAMAMOTO
Research29 Dec 1956
Nature

Volume: 178, P: 1466
The aesthetic nature of the birthing room environment may alter the need for obstetrical interventions – an observational retrospective cohort study

Tine Wrønding
Aikaterini Argyraki
Ellen C. L. Løkkegaard
ResearchOpen Access22 Jan 2019
Scientific Reports

Volume: 9, P: 1-7
An Uncommon Type of Bacteriophage

PAUL H. KOPPER
GRETA LONG
Research23 Feb 1952
Nature

Volume: 169, P: 331-332
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

Shyam Prabhakar, Paul Robson, Iain Beehuat Tan and colleagues characterize the cellular heterogeneity of colorectal tumors and their microenvironment on the basis of single-cell RNA–seq data analyzed with their newly developed clustering algorithm, reference component analysis (RCA). Their analyses identify two subtypes of cancer-associated fibroblasts and further divide tumors into subgroups with divergent survival probabilities.

Huipeng Li
Elise T Courtois
Shyam Prabhakar
Research20 Mar 2017
Nature Genetics

Volume: 49, P: 708-718
Olefinic Nature of Anacardic Acid from Indian Cashew-nut Shell Liquid

V. J. PAUL
LOURDU M. YEDDANAPALLI
Research25 Sept 1954
Nature

Volume: 174, P: 604
Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients.

Lyndon da Cruz
Kate Fynes
Peter J Coffey
Research19 Mar 2018
Nature Biotechnology

Volume: 36, P: 328-337
Napoleon Bonaparte—no evidence of chronic arsenic poisoning

Peter K. Lewin
Ronald G. V. Hancock
Paul Voynovich
Research14 Oct 1982
Nature

Volume: 299, P: 627-628
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Response of the Pigeon Crop Gland to Prolactin: Inhibition by Œstradiol Monobenzoate

S. J. FOLLEY
PAUL WHITE
Research18 Sept 1937
Nature

Volume: 140, P: 505
Difference in the Behaviour of Eu- and Hetero-chromatin: Crossing-over

PAUL A. ROBERTS
Research01 Feb 1965
Nature

Volume: 205, P: 725-726
Evidence against Ha-ras-1 involvement in sporadic and familial melanoma

Daniela S. Gerhard
Nicholas C. Dracopoli
David E. Housman
Research01 Jan 1987
Nature

Volume: 325, P: 73-75
A rapidly closing window for coral persistence under global warming

Global warming is causing widespread coral mortality through bleaching. Here, simulations of coral eco-evolutionary dynamics forecast strong population declines in the 21st century. Coral reefs may collapse by 2100, unless global warming is limited to 2 °C, enabling corals to adapt and persist.

Yves-Marie Bozec
Arne A. S. Adam
Peter J. Mumby
ResearchOpen Access05 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Author Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

Huipeng Li
Elise T Courtois
Shyam Prabhakar
Amendments and Corrections12 Nov 2018
Nature Genetics

Volume: 50, P: 1754
Publisher Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

Huipeng Li
Elise T. Courtois
Shyam Prabhakar
Amendments and Corrections19 Dec 2022
Nature Genetics

Volume: 55, P: 166
Genetic engineering of harvest index in tobacco through overexpression of a phytochrome gene

Paul R.H. Robson
Alex C. McCormac
Harry Smith
Research01 Aug 1996
Nature Biotechnology

Volume: 14, P: 995-998
Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells

Travis Jerde
Zhong Wu
Wade Bushman
ResearchOpen Access01 Apr 2010
Nature Precedings

P: 1
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Left over life to kill

A shot at redemption.

Paul Alex Gray
Comments & Opinion26 Feb 2020
Nature
Author Correction: Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Yuliana Tan
William F. Flynn
Elise T. Courtois
Amendments and Corrections29 Sept 2022
Nature Cell Biology

Volume: 24, P: 1679
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
An interaction between vinculin and talin

Keith Burridge
Paul Mangeat
Research19 Apr 1984
Nature

Volume: 308, P: 744-746
Rhizobium nod genes are involved in inducing an early nodulin gene

Francine Govers
Marja Moerman
Ton Bisseling
Research09 Oct 1986
Nature

Volume: 323, P: 564-566
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

Fritz H. Bach
Christiane Ferran
Waune W. Hancock
Research01 Feb 1997
Nature Medicine

Volume: 3, P: 196-204
The Universe at high redshift

Bob Carswell
Paul Hewett
News & Views11 Jan 1990
Nature

Volume: 343, P: 117-118
A functional role for vasoactive intestinal polypeptide in anterior cingulate cortex

James McCulloch
Paul A. T. Kelly
Research04 Aug 1983
Nature

Volume: 304, P: 438-440
A common molecular basis for three inherited kidney stone diseases

Sarah E. Lloyd
Simon H. S. Pearce
Rajesh V. Thakker
Research01 Feb 1996
Nature

Volume: 379, P: 445-449
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

C. Eric Bronner
Sean M. Baker
R. Michael Liskay
Research17 Mar 1994
Nature

Volume: 368, P: 258-261
Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

Paul Hasty
Ramiro Ramírez-Solis
Allan Bradley
Research21 Mar 1991
Nature

Volume: 350, P: 243-246
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Outcomes in verteporfin photodynamic therapy for choroidal neovascularisation—‘beyond the TAP study’

R M Barnes
L Gee
S P Harding
Research13 Feb 2004
Eye

Volume: 18, P: 809-813
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Reply to: Revisiting life history and morphological proxies for early mammaliaform metabolic rates

Elis Newham
Pamela G. Gill
Ian J. Corfe
ResearchOpen Access23 Sept 2022
Nature Communications

Volume: 13, P: 1-4
Advancing biological understanding of cellular senescence with computational multiomics

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

Sheng Li
Paula A. Agudelo Garcia
Rong Fan
Reviews15 Sept 2025
Nature Genetics

Volume: 57, P: 2381-2394
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

Fergus J. Couch
Karoline B. Kuchenbaecker
Antonis C. Antoniou
ResearchOpen Access27 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Inclusive fitness theory and eusociality

Patrick Abbot
Jun Abe
Andrew Zink
Research23 Mar 2011
Nature

Volume: 471, P: E1-E4
Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery

George S. Liu
Soraya Fereydooni
Konstantina M. Stankovic
ResearchOpen Access10 May 2025
npj Digital Medicine

Volume: 8, P: 1-7
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
A canine distemper virus epidemic in Serengeti lions (Panthera leo)

Melody E. Roelke-Parker
Linda Munson
Max J. G. Appel
Research01 Feb 1996
Nature

Volume: 379, P: 441-445
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Protein-altering germline mutations implicate novel genes related to lung cancer development

In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.

Xuemei Ji
Semanti Mukherjee
Christopher I. Amos
ResearchOpen Access11 May 2020
Nature Communications

Volume: 11, P: 1-14
‘Pulsed’ immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease

Paul A R Meyer
Peter G Watson
Paul Dubord
Research01 Jul 1987
Eye

Volume: 1, P: 487-495
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Evolution of Agriculture

PAUL C. MANGELSDORF
Books & Arts29 Nov 1969
Nature

Volume: 224, P: 927-928
Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

Elizabeth D. Getzoff
John A. Tainer
David C. Richardson
Research17 Nov 1983
Nature

Volume: 306, P: 287-290
Single-cell, whole-embryo phenotyping of mammalian developmental disorders

A study reports single-cell RNA-sequencing profiles for more than 1.6 million cell nuclei from 101 whole mouse embryos including 22 mutant and 4 wild-type genotypes, from one experiment.

Xingfan Huang
Jana Henck
Malte Spielmann
ResearchOpen Access15 Nov 2023
Nature

Volume: 623, P: 772-781

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