Recent clinical trials have raised questions about the perceived advantages of second-generation 'atypical' antipsychotics over older drugs. This article discusses how broadening of the concept of 'atypicality' — originally related purely to a lack of extrapyramidal side effects — might have hampered the search for better antipsychotics, and proposes that redefining the concept could be key for breakthroughs in schizophrenia therapy.
- Gerhard Gründer
- Hanns Hippius
- Arvid Carlsson
