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Showing 1–2 of 2 results
Advanced filters: Author: Paul Talman Clear advanced filters

  • In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying a promising combination therapy of baricitinib, memantine and riluzole.

    • Christopher R. Bye
    • Elizabeth Qian
    • Bradley J. Turner
    ResearchOpen Access
    Nature Neuroscience
    Volume: 29, P: 40-52

  • The identification of pathogenic targets in amyotrophic lateral sclerosis means that effective therapies are increasingly likely. In this Review, Kiernan et al. discuss advances towards therapy and the innovations needed in clinical trials to facilitate the translation into treatments for patients.

    • Matthew C. Kiernan
    • Steve Vucic
    • Martin R. Turner
    Reviews
    Nature Reviews Neurology
    Volume: 17, P: 104-118