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Advanced filters: Author: Paula Nunes-Hasler Clear advanced filters

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

STIM proteins sense Ca²⁺ depletion in the ER and activate store-operated Ca²⁺ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

Sophia Maschalidi
Paula Nunes-Hasler
Bénédicte Manoury
ResearchOpen Access21 Nov 2017
Nature Communications

Volume: 8, P: 1-16
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

STIM proteins sense Ca²⁺ depletion in the ER and activate store-operated Ca²⁺-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation.

Paula Nunes-Hasler
Sophia Maschalidi
Nicolas Demaurex
ResearchOpen Access24 Nov 2017
Nature Communications

Volume: 8, P: 1-15
Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites

Sec22b controls phagosome maturation by tethering ER-phagosome membrane contact sites independently of the tether STIM1.

Nina Criado Santos
Samuel Bouvet
Paula Nunes-Hasler
ResearchOpen Access04 Oct 2023
Communications Biology

Volume: 6, P: 1-17

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