Nature Search

Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

Sottoriva and colleagues combine next-generation sequencing and AI-aided histopathology to assess tumor evolvability in patient samples with long-term follow-up and find that it can be a strong predictor of recurrence in high-risk prostate cancer.

Javier Fernandez-Mateos
George D. Cresswell
Andrea Sottoriva
ResearchOpen Access12 Jul 2024
Nature Cancer

Volume: 5, P: 1334-1351
Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Reliable detection of mutations below 0.5% variant allele frequency remains a key challenge for circulating tumor DNA sequencing assays.

Ira W. Deveson
Binsheng Gong
Joshua Xu
Research12 Apr 2021
Nature Biotechnology

Volume: 39, P: 1115-1128
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer

Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate with markers of HR deficiency but HR deficiency was detected in 69% of tumours, indicating that PARP inhibitors may be a useful treatment.

Neha Chopra
Holly Tovey
Nicholas C. Turner
ResearchOpen Access29 May 2020
Nature Communications

Volume: 11, P: 1-12
Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

Kevin Litchfield
Max Levy
Clare Turnbull
ResearchOpen Access20 Dec 2016
Nature Communications

Volume: 7, P: 1-8
Signatures of copy number alterations in human cancer

A new framework enables a pan-cancer reference set of copy number signatures derived from allele-specific profiles from different experimental assays.

Christopher D. Steele
Ammal Abbasi
Nischalan Pillay
ResearchOpen Access15 Jun 2022
Nature

Volume: 606, P: 984-991
Genomic landscape of platinum resistant and sensitive testicular cancers

Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.

Chey Loveday
Kevin Litchfield
Clare Turnbull
ResearchOpen Access04 May 2020
Nature Communications

Volume: 11, P: 1-12
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

Rearrangements of the Ig loci are essential for generating antibody diversity but abnormal translocations can be a driving event for myeloma. Here Walker et al. perform whole exome sequencing on myeloma patients to capture the diversity of mutational changes.

Brian A. Walker
Christopher P. Wardell
Gareth J. Morgan
Research23 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Incidental finding of leukaemia in circulating tumour DNA— the importance of a molecular tumour board

Justin Mencel
Neha Rayarel
Naureen Starling
ResearchOpen Access13 Feb 2024
BJC Reports

Volume: 2, P: 1-4

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