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Showing 1–5 of 5 results
Advanced filters: Author: Paulina K. Sydor Clear advanced filters

  • Enacyloxin IIa is an antibiotic, assembled by a modular polyketide synthase, with promising activity against the Gram-negative bacterium Acinetobacter baumannii. Now, it has been shown that the enacyloxin IIa polyketide chain is released via transfer to a separately encoded carrier protein by a non-elongating ketosynthase domain, followed by condensation with 3,4-dihydroxycyclohexane carboxylic acid by a non-ribosomal peptide synthetase condensation domain.

    • Joleen Masschelein
    • Paulina K. Sydor
    • Gregory L. Challis
    Research
    Nature Chemistry
    Volume: 11, P: 906-912

  • The antibiotic enacyloxin IIa is assembled by a modular polyketide synthase, and released from it by condensation of the enacyloxin acyl chain with 3,4-dihydroxycyclohexane carboxylic acid. A multipronged approach shows the structural basis for recognition between the peptidyl carrier protein domain that bears the acyl chain and the non-ribosomal peptide synthetase condensation domain that ligates it with the carboxylic acid.

    • Simone Kosol
    • Angelo Gallo
    • Józef R. Lewandowski
    Research
    Nature Chemistry
    Volume: 11, P: 913-923

  • X-ray crystallography and cryo-electron microscopy structures of the transcriptional repressor of the methylomycin gene cluster, MmfR, reveal the molecular basis for regulation of antibiotic biosynthesis by AHFCA hormones in Actinobacteria.

    • Shanshan Zhou
    • Hussain Bhukya
    • Christophe Corre
    Research
    Nature
    Volume: 590, P: 463-467

  • Enzyme-mediated oxidative cyclizations in nature are a powerful demonstration of the utility of selective C–H activation. Here, Rieske oxygenase-like enzymes RedG and McpG are shown to mediate regio- and stereodivergent carbocyclization of undecylprodigiosin to streptorubin B and metacycloprodigiosin, respectively. Understanding these remarkably selective C–H activations could inspire the design of biomimetic catalysts with similar capabilities.

    • Paulina K. Sydor
    • Sarah M. Barry
    • Gregory L. Challis
    Research
    Nature Chemistry
    Volume: 3, P: 388-392