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Showing 1–8 of 8 results
Advanced filters: Author: Pauline Chabosseau Clear advanced filters

  • Mutations in the DNA helicaseBLM cause Bloom syndrome, which is characterized by slow replication fork progression and genetic instability. Here, cells lacking BLMare shown to have a defect in cytidine deaminase, which alters the pyrimidine pool and results in replication fork progression with altered velocity.

    • Pauline Chabosseau
    • Géraldine Buhagiar-Labarchède
    • Mounira Amor-Guéret
    Research
    Nature Communications
    Volume: 2, P: 1-6

  • Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.

    • Elina Akalestou
    • Kinga Suba
    • Guy A. Rutter
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Zinc is important for normal immunity but its mechanistic actions are poorly understood. Hambleton and colleagues identify defects in Zn2+ transport that underpin a novel human immunodeficiency characterized by loss of mature B cells.

    • Consuelo Anzilotti
    • David J. Swan
    • Sophie Hambleton
    Research
    Nature Immunology
    Volume: 20, P: 350-361

  • The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

    • Om Prakash Dwivedi
    • Mikko Lehtovirta
    • Leif Groop
    Research
    Nature Genetics
    Volume: 51, P: 1596-1606

  • Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release.

    • Ben Jones
    • Teresa Buenaventura
    • Stephen R. Bloom
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Over the past 10 years, evidence has accumulated to suggest that α-cells are involved in the development of diabetes mellitus. This Review outlines our current understanding of α-cells and discusses how they could be targeted in the treatment of diabetes mellitus.

    • Jesper Gromada
    • Pauline Chabosseau
    • Guy A. Rutter
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 694-704