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Showing 1–3 of 3 results

Advanced filters: Author: Pavol Genzor Clear advanced filters

Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi protein, through mutation of its specificity loop.

Chad B. Stein
Pavol Genzor
Astrid D. Haase
ResearchOpen Access19 Feb 2019
Nature Communications

Volume: 10, P: 1-8
Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Sepsis is a global challenge and a significant burden in Sub-Saharan Africa. Here, Chenoweth et al profile host gene expression signatures from a cohort in Ghana to define molecular phenotypes and identify potential targets to improve patient outcomes.

Josh G. Chenoweth
Carlo Colantuoni
Danielle V. Clark
ResearchOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-13
Sepsis endotypes identified by host gene expression across global cohorts

Chenoweth et al. investigate heterogeneity in sepsis using host gene expression from multi-site international cohorts. Endotypes differentiated by mortality are identified and related molecular signatures implicate immune dysfunction in sepsis pathophysiology.

Josh G. Chenoweth
Joost Brandsma
Danielle V. Clark
ResearchOpen Access18 Jun 2024
Communications Medicine

Volume: 4, P: 1-9