Nature Search

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

P Swietach
A Hulikova
A L Harris
Reviews04 Oct 2010
Oncogene

Volume: 29, P: 6509-6521
T-cells produce acidic niches in lymph nodes to suppress their own effector functions

T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-presenting cells.

Hao Wu
Veronica Estrella
Robert J. Gillies
ResearchOpen Access17 Aug 2020
Nature Communications

Volume: 11, P: 1-13
Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm

Sarah L. Richardson
Pawel Swietach
ResearchOpen Access25 Oct 2016
Scientific Reports

Volume: 6, P: 1-11
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Metabolism can influence gene expression through histone modifications. Using a mouse model of the inborn error of metabolism propionic acidaemia, Park et al. show how raised propionate levels produce epigenetic actions that impact cardiac function.

Kyung Chan Park
Nicholas T. Crump
Pawel Swietach
ResearchOpen Access23 Nov 2023
Nature Cardiovascular Research

Volume: 2, P: 1221-1245
How protons pave the way to aggressive cancers

In this Review, Swietach and colleagues discuss how the pH balance is dysregulated in tumours and how alterations in intracellular and extracellular pH affect tumour biology to accelerate disease progression, providing a rationale for therapeutic targeting of acid–base disturbances in cancer.

Pawel Swietach
Ebbe Boedtkjer
Stine Falsig Pedersen
Reviews26 Oct 2023
Nature Reviews Cancer

Volume: 23, P: 825-841
Autoregulation of H⁺/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

Wiktoria Blaszczak
Hannah Williams
Pawel Swietach
ResearchOpen Access15 Jul 2022
British Journal of Cancer

Volume: 127, P: 1365-1377
Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Johanna Michl et al. use real-time pH measurements of cell culture media and intracellular pH data from live-cell culture conditions to explore the effects of commonly-used buffers. Based on these data, they propose guidelines for controlling pH in cell culture systems and improving reproducibility.

Johanna Michl
Kyung Chan Park
Pawel Swietach
ResearchOpen Access26 Apr 2019
Communications Biology

Volume: 2, P: 1-12
Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Shen-Han Lee
Dominick McIntyre
John R. Griffiths
ResearchOpen Access12 Sept 2018
British Journal of Cancer

Volume: 119, P: 622-630
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

T H Dovmark
M Saccomano
P Swietach
ResearchOpen Access03 Apr 2017
Oncogene

Volume: 36, P: 4538-4550

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